Аннотация

The black bean (Phaseolus vulgaris L.), a nutrient-dense legume containing bioactive compounds, has proven to have excellent antioxidant and anti-anflammatory effects. However, the available literature data are diverse and needs summarizing. Therefore, we aimed to systematically review the studies on the antioxidant and anti-inflammatory activities of the black bean. A literature search following the PRISMA guidelines was carried out for in vitro, in vivo, and human studies assessing the antioxidant and anti-inflammatory effects of the black bean. For this, we used Boolean operators in the following databases: PUBMED, DOAJ, Google Scholar, and WHO’s International Clinical Trials Registry Platform. A total of 411 articles was screened, with 28 duplicate articles removed. Among the remaining 383 articles, only 38 matched the inclusion criteria. The risks of bias were evaluated using the QUIN tool for the in vitro studies and the OHAT tool for the in vivo and human studies. The seed coat of the black bean exhibited the strongest antioxidant and anti-inflammatory activities compared to the other parts of the seed. While thermal processing negatively impacted the beneficial effects, the retention of the cooking water improved the beans’ antioxidant and anti-inflammatory activities. Germinated and fermented black beans had higher potential than raw and cooked beans. Thus, the black bean can exert a protective effect against inflammatory cytokines. The antioxidant and anti-inflammatory activities of the black bean depend on which parts of the bean are used and how they are processed. There is a need for further studies and clinical trials to focus on the beneficial role of germinated and fermented black beans in human health.

Ключевые слова

Beans, legumes, oxidative stress, inflammation, bioactive compounds, therapeutic application

СПИСОК ЛИТЕРАТУРЫ

1. Malta DC, Duncan BB, Schmidt MI, Teixeira R, Ribeiro ALP, Felisbino-Mendes MS, et al. Trends in mortality due to non-communicable diseases in the Brazilian adult population: national and subnational estimates and projections for 2030. Population Health Metrics. 2020;18:16. https://doi.org/10.1186/s12963-020-00216-1
2. Global, regional, and national burden of diabetes from 1990 to 2021, with projections of prevalence to 2050: A systematic analysis for the Global Burden of Disease Study 2021. The Lancet. 2023;402(10397):203–234. https://doi.org/10.1016/S0140-6736(23)01301-6
3. Roth GA, Mensah GA, Johnson CO, Addolorato G, Ammirati E, Baddour LM, et al. Global burden of cardiovascular diseases and risk factors, 1990-2019: Update from the GBD 2019 study. Journal of the American College of Cardiology. 2020;76(25):2982–3021. https://doi.org/10.1016/j.jacc.2020.11.010
4. Vaduganathan M, Mensah GA, Turco JV, Fuster V, Roth GA. The global burden of cardiovascular diseases and risk: A compass for future health. Journal of the American College of Cardiology. 2022;80(25):2361–2371. https://doi.org/10.1016/j.jacc.2022.11.005
5. Bray F, Laversanne M, Sung H, Ferlay J, Siegel RL, Soerjomataram I, et al. Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA: A Cancer Journal for Clinicians. 2024;74(3):229–263. https://doi.org/10.3322/caac.21834
6. Jomova K, Raptova R, Alomar SY, Alwasel SH, Nepovimova E, Kuca K, et al. Reactive oxygen species, toxicity, oxidative stress, and antioxidants: Chronic diseases and aging. Archives of Toxicology. 2023;97:2499–2574. https://doi.org/10.1007/s00204-023-03562-9
7. Pizzino G, Irrera N, Cucinotta M, Pallio G, Mannino F, Arcoraci V, et al. Oxidative stress: Harms and benefits for human health. Oxidative Medicine and Cellular Longevity. 2017;2017(1). https://doi.org/10.1155/2017/8416763
8. Leyane TS, Jere SW, Houreld NN. Oxidative stress in ageing and chronic degenerative pathologies: Molecular mechanisms involved in counteracting oxidative stress and chronic inflammation. International Journal of Molecular Sciences. 2022;23(13):7273. https://doi.org/10.3390/ijms23137273
9. Furman D, Campisi J, Verdin E, Carrera-Bastos P, Targ S, Franceschi C, et al. Chronic inflammation in the etiology of disease across the life span. Nature Medicine. 2019;25:1822–1832. https://doi.org/10.1038/s41591-019-0675-0
10. Aleksandrova K, Koelman L, Rodrigues CE. Dietary patterns and biomarkers of oxidative stress and inflammation: A systematic review of observational and intervention studies. Redox Biology. 2021;42:101869. https://doi.org/10.1016/j.redox.2021.101869
11. Baker MT, Lu P, Parrella JA, Leggette HR. Consumer acceptance toward functional foods: A scoping review. International Journal of Environmental Research and Public Health. 2022;19(3):1217. https://doi.org/10.3390/ijerph19031217
12. Ding Y, Ban Q, Wu Y, Sun Y, Zhou Z, Wang Q, et al. Effect of high hydrostatic pressure on the edible quality, health and safety attributes of plant-based foods represented by cereals and legumes: A review. Critical Reviews in Food Science and Nutrition. 2023;63(20):4636–4654. https://doi.org/10.1080/10408398.2021.2005531
13. Sharif HR, Williams PA, Sharif MK, Abbas S, Majeed H, Masamba KG, et al. Current progress in the utilization of native and modified legume proteins as emulsifiers and encapsulants – A review. Food Hydrocolloids. 2018;76:2–16. https://doi.org/10.1016/j.foodhyd.2017.01.002
14. Lukus PK, Doma KM, Duncan AM. The role of pulses in cardiovascular disease risk for adults with diabetes. American Journal of Lifestyle Medicine. 2020;14(6):571–584. https://doi.org/10.1177/1559827620916698
15. Angeles JGC, Villanueva JC, Uy LYC, Mercado SMQ, Tsuchiya MCL, Lado JP, et al. Legumes as functional food for cardiovascular disease. Applied Sciences. 2021;11(12):5475. https://doi.org/10.3390/app11125475
16. Jaiswal SK, Dakora FD. Seed-coat pigmentation plays a crucial role in partner selection and N2 fixation in legume-root–microbe associations in african soils. Plants. 2024;13(11):1464. https://doi.org/10.3390/plants13111464
17. Meenu M, Chen P, Mradula M, Chang SKC, Xu B. New insights into chemical compositions and health-promoting effects of black beans (Phaseolus vulgaris L.). Food Frontiers. 2023;4(3):1019–1038. https://doi.org/10.1002/fft2.246
18. Melini F, Lisciani S, Camilli E, Marconi S, Melini V. Effect of cooking on phenolic compound content and in vitro bioaccessibility in sustainable foods: A case study on black beans. Sustainability. 2024;16(1):279. https://doi.org/10.3390/su16010279
19. Hernandez-Velazquez I, Sanchez-Tapia M, Ordaz-Nava G, Torres N, Tovar AR, Galvez A. Black bean protein concentrate ameliorates hepatic steatosis by decreasing lipogenesis and increasing fatty acid oxidation in rats fed a high fat-sucrose diet. Food and Function. 2020;11:10341–10350. https://doi.org/10.1039/d0fo02258f
20. Beans, black turtle, mature seeds, raw [Internet]. [cited 2024 May 3]. Available from: https://fdc.nal.usda.gov/fdc-app.html#/food-details/175186/nutrients
21. Feng Z, Dou W, Alaxi S, Niu Y, Yu L. Modified soluble dietary fiber from black bean coats with its rheological and bile acid binding properties. Food Hydrocolloids. 2017;62:94–101. https://doi.org/10.1016/j.foodhyd.2016.07.032
22. Thompson SV, Winham DM, Hutchins AM. Traditional bean and rice meals reduce postprandial glycemia in adults with type 2 diabetes: A cross-over study. Nutrition Journal. 2012;11:23. https://doi.org/10.1186/1475-2891-11-23
23. Contreras J, Alcázar-Valle M, Lugo-Cervantes E, Luna-Vital DA, Mojica L. Mexican native black bean anthocyanin-rich extracts modulate biological markers associated with inflammation. Pharmaceuticals. 2023;16(6):874. https://doi.org/10.3390/ph16060874
24. Cruz-Bravo RK, Guajardo-Flores D, Gómez-Aldapa CA, Castro-Rosas J, Navarro-Cortez RO, Díaz-Batalla L, et al. Spray-dried microencapsulation of bean coat flour (Phaselus vulgaris, L.) bioactive compounds: Optimization, functional activity, and storage. CYTA – Journal of Food. 2023;21(1):493–501. https://doi.org/10.1080/19476337.2023.2226186
25. Mali PS, Kumar P. Optimization of microwave assisted extraction of bioactive compounds from black bean waste and evaluation of its antioxidant and antidiabetic potential in vitro. Food Chemistry Advances. 2023;3:100543. https://doi.org/10.1016/j.focha.2023.100543
26. Bramer WM, Rethlefsen ML, Kleijnen J, Franco OH. Optimal database combinations for literature searches in systematic reviews: A prospective exploratory study. Systematic Reviews. 2017;6:245. https://doi.org/10.1186/s13643-017-0644-y
27. Sheth VH, Shah NP, Jain R, Bhanushali N, Bhatnagar V. Development and validation of a risk-of-bias tool for assessing in vitro studies conducted in dentistry: The QUIN. The Journal of Prosthetic Dentistry. 2024;131(6):P1038–1042. https://doi.org/10.1016/j.prosdent.2022.05.019
28. Handbook for conducting a literature-based health assessment using ohat approach for systematic review and evidence integration [Internet]. [cited 2024 May 3]. Available from: https://ntp.niehs.nih.gov/whatwestudy/assessments/noncancer/handbook/index.html
29. Chen Y, Zheng Z, Ai Z, Zhang Y, Tan CP, Liu Y. Exploring the antioxidant and structural properties of black bean protein hydrolysate and its peptide fractions. Frontiers in Nutrition. 2022;9:884537. https://doi.org/10.3389/fnut.2022.884537
30. Liu W, Dun M, Liu X, Zhang G, Ling J. Effects on total phenolic and flavonoid content, antioxidant properties, and angiotensin I-converting enzyme inhibitory activity of beans by solid-state fermentation with Cordyceps militaris. International Journal of Food Properties. 2022;25(1):477–491. https://doi.org/10.3389/fnut.2022.884537
31. Flores-Medellín SA, Camacho-Ruiz RM, Guízar-González C, Rivera-Leon EA, Llamas-Covarrubias IM, Mojica L. Protein hydrolysates and phenolic compounds from fermented black beans inhibit markers related to obesity and type-2 diabetes. Legume Science. 2021;3(1):e64. https://doi.org/10.1002/leg3.64
32. Abdulrahman BO, Bala M, Bello OM. Evaluation of in vitro antioxidant and antidiabetic potential of extracts from Phaseolus vulgaris L. seeds (Black turtle beans). Functional Food Science. 2021;1(9):23–38. https://doi.org/10.31989/ffs.v1i9.821
33. Perez-Hernandez LM, Hernández-Álvarez AJ, Morgan M, Boesch C, Orfila C. Polyphenol bioaccessibility and anti-inflammatory activity of Mexican common beans (Phaseolus vulgaris L.) with diverse seed colour. CYTA – Journal of Food. 2021;19(1):682–690. https://doi.org/10.1080/19476337.2021.1965660
34. Rodriguez Madrera R, Campa Negrillo A, Suárez Valles B, Ferreira Fernández JJ. Phenolic content and antioxidant activity in seeds of common bean (Phaseolus vulgaris L.). Foods. 2021;10(4):864. https://doi.org/10.3390/foods10040864
35. Hernandez DF, Orozco-Avila I, Lugo-Cervantes E, Mojica L. Black bean (Phaseolus vulgaris L.) phenolic extract exhibits antioxidant and anti-aging potential. Current Developments in Nutrition. 2020;4. https://doi.org/10.1093/cdn/nzaa040_024
36. Viktorinová K, Petřeková K, Šimek J, Hartman I, Hertel V. Nutrition and sensory evaluation of germinated legumes. Kvasny Prumysl. 2020;66(3):270–276. https://doi.org/10.18832/kp2019.66.270
37. Carbas B, Machado N, Oppolzer D, Ferreira L, Queiroz M, Brites C, et al. Nutrients, antinutrients, phenolic composition, and antioxidant activity of common bean cultivars and their potential for food applications. Antioxidants. 2020;9(2):186. https://doi.org/10.3390/antiox9020186
38. Hsieh-Lo M, Castillo-Herrera G, Mojica L. Black bean anthocyanin-rich extract from supercritical and pressurized extraction increased in vitro antidiabetic potential, while having similar storage stability. Foods. 2020;9(5):655. https://doi.org/10.3390/foods9050655
39. Teixeira JE, Bragada JA, Bragada JP, Coelho JP, Pinto IG, Reis LP, et al. Structural equation modelling for predicting the relative contribution of each component in the metabolic syndrome status change. International Journal of Environmental Research and Public Health. 2022;19(6):3384. https://doi.org/10.3390/ijerph19063384
40. Nkenmeni DC, Kotue TC, Kumar P, Djouhou FM, Ngo SF, Pieme AC, et al. HPLC profiling, in vitro antisickling and antioxidant activities of phenolic compound extracts from black bean seeds (Phaseolus vulgarus L.) used in the management of sickle cell disease in the West Region of Cameroon. International Journal of Food and Nutrition Research. 2019;3:30. https://doi.org/10.28933/ijfnr-2019-08-0105
41. Zhang Y, Pechan T, Chang SKC. Antioxidant and angiotensin-I converting enzyme inhibitory activities of phenolic extracts and fractions derived from three phenolic-rich legume varieties. Journal of Functional Foods. 2018;42:289–297. https://doi.org/10.1016/j.jff.2017.12.060
42. Herrera-Hernández IM, Armendáriz-Fernández KV, Muñoz-Márquez E, Sida-Arreola JP, Sánchez E. Characterization of bioactive compounds, mineral content and antioxidant capacity in bean varieties grown in semi-arid conditions in Zacatecas, Mexico. Foods. 2018;7(12):199. https://doi.org/10.3390/foods7120199
43. Mastura YH, Hasnah H, Dang TN. Total phenolic content and antioxidant capacity of beans: Organic vs inorganic. International Food Research Journal. 2017;24(2):510–517.
44. López-Barrios L, Antunes-Ricardo M, Gutiérrez-Uribe JA. Changes in antioxidant and antiinflammatory activity of black bean (Phaseolus vulgaris L.) protein isolates due to germination and enzymatic digestion. Food Chemistry. 2016;203:417–424. https://doi.org/10.1016/j.foodchem.2016.02.048
45. do Evangelho JA, Berrios JJ, Pinto VZ, Antunes MD, Vanier NL, Zavareze ER. Antioxidant activity of black bean (Phaseolus vulgaris L.) protein hydrolysates. Food Science and Technology. 2016;36:23–27. https://doi.org/10.1590/1678-457X.0047
46. Xue Z, Wang C, Zhai L, Yu W, Chang H, Kou X, et al. Bioactive compounds and antioxidant activity of mung bean (Vigna radiata L.), soybean (Glycine max L.) and black bean (Phaseolus vulgaris L.) during the germination process. Czech Journal of Food Sciences. 2016;34(1):68–78. https://doi.org/10.17221/434/2015-CJFS
47. Ombra MN, d’Acierno A, Nazzaro F, Riccardi R, Spigno P, Zaccardelli M, et al. Phenolic composition and antioxidant and antiproliferative activities of the extracts of twelve common bean (Phaseolus vulgaris L.) endemic ecotypes of southern italy before and after cooking. Oxidative Medicine and Cellular Longevity. 2016;2016(1):1398298. https://doi.org/10.1155/2016/1398298
48. Mojica L, Meyer A, Berhow MA, de Mejía EG. Bean cultivars (Phaseolus vulgaris L.) have similar high antioxidant capacity, in vitro inhibition of α-amylase and α-glucosidase while diverse phenolic composition and concentration. Food Research International. 2015;69:38–48. https://doi.org/10.1016/j.foodres.2014.12.007
49. Guajardo-Flores D, Serna-Saldívar SO, Gutiérrez-Uribe JA. Evaluation of the antioxidant and antiproliferative activities of extracted saponins and flavonols from germinated black beans (Phaseolus vulgaris L.). Food Chemistry. 2013;141(2):1497–1503. https://doi.org/10.1016/j.foodchem.2013.04.010
50. Xu B, Chang SKC. Comparative study on antiproliferation properties and cellular antioxidant activities of commonly consumed food legumes against nine human cancer cell lines. Food Chemistry. 2012;134(3):1287–1296. https://doi.org/10.1016/j.foodchem.2012.02.212
51. Golam Masum Akond ASM, Khandaker L, Berthold J, Gates L, Peters K, Delong H, et al. Anthocyanin, total polyphenols and antioxidant activity of common bean. American Journal of Food Technology. 2011;6(5):385–394. https://doi.org/10.3923/ajft.2011.385.394
52. Xu B, Chang SKC. Reduction of antiproliferative capacities, cell-based antioxidant capacities and phytochemical contents of common beans and soybeans upon thermal processing. Food Chemistry. 2011;129(3):974–981. https://doi.org/10.1016/j.foodchem.2011.05.057
53. Hernández-Salazar M, Osorio-Diaz P, Loarca-Piña G, Reynoso-Camacho R, Tovar J, Bello-Pérez LA. In vitro fermentability and antioxidant capacity of the indigestible fraction of cooked black beans (Phaseolus vulgaris L.), lentils (Lens culinaris L.) and chickpeas (Cicer arietinum L.). Journal of the Science of Food and Agriculture. 2010;90(9):1417–1422. https://doi.org/10.1002/jsfa.3954
54. Silva-Cristobal L, Osorio-Díaz P, Tovar J, Bello-Pérez LA. Chemical composition, carbohydrate digestibility, and antioxidant capacity of cooked black bean, chickpea, and lentil Mexican varieties. CYTA – Journal of Food. 2010;8(1):7–14. https://doi.org/10.1080/19476330903119218
55. Oomah BD, Corbé A, Balasubramanian P. Antioxidant and anti-inflammatory activities of bean (Phaseolus vulgaris L.) hulls. Journal of Agricultural and Food Chemistry. 2010;58(14):8225–8230. https://doi.org/10.1021/jf1011193
56. Xu B, Chang SKC. Total phenolic, phenolic acid, anthocyanin, flavan-3-ol, and flavonol profiles and antioxidant properties of pinto and black beans (Phaseolus vulgaris L.) as affected by thermal processing. Journal of Agricultural and Food Chemistry. 2009;57(11):4754–4764. https://doi.org/10.1021/jf900695s
57. Dong M, He X, Rui HL. Phytochemicals of black bean seed coats: Isolation, structure elucidation, and their antiproliferative and antioxidative activities. Journal of Agricultural and Food Chemistry. 2007;55(15):6044–6051. https://doi.org/10.1021/jf070706d
58. Tan Y, Tam CC, Meng S, Zhang Y, Alves P, Yokoyama W. Cooked black turtle beans ameliorate insulin resistance and restore gut microbiota in C57BL/6J mice on high-fat diets. Foods. 2021;10(8):1691. https://doi.org/10.3390/foods10081691
59. Monk JM, Wu W, Hutchinson AL, Pauls P, Robinson LE, Power KA. Navy and black bean supplementation attenuates colitis-associated inflammation and colonic epithelial damage. The Journal of Nutritional Biochemistry. 2018;56:215–223. https://doi.org/10.1016/j.jnutbio.2018.02.013
60. Wang J-Y, Zhu C, Qian T-W, Guo H, Wang D-D, Zhang F, et al. Extracts of black bean peel and pomegranate peel ameliorate oxidative stress-induced hyperglycemia in mice. Experimental and Therapeutic Medicine. 2015;9(1):43–48. https://doi.org/10.3892/etm.2014.2040
61. Zhang C, Monk JM, Lu JT, Zarepoor L, Wu W, Liu R, et al. Cooked navy and black bean diets improve biomarkers of colon health and reduce inflammation during colitis. British Journal of Nutrition. 2014;111(9):1549–1563. https://doi.org/10.1017/S0007114513004352
62. Reverri EJ, Randolph JM, Steinberg FM, Tissa Kappagoda C, Edirisinghe I, Burton-Freeman BM. Black beans, fiber, and antioxidant capacity pilot study: Examination of whole foods vs. functional components on postprandial metabolic, oxidative stress, and inflammation in adults with metabolic syndrome. Nutrients. 2015;7(8):6139–6154. https://doi.org/10.3390/nu7085273
63. Abdulrahman BO, Bala M, Bello OM. Bioactive compounds of black bean (Phaseolus vulgaris L.). In: Murthy HN, Paek K-Y, editors. Bioactive compounds in underutilized vegetables and legumes. Cham: Springer; 2020. https://doi.org/10.1007/978-3-030-44578-2_38-1
64. Teixeira-Guedes CI, Oppolzer D, Barros AI, Pereira-Wilson C. Impact of cooking method on phenolic composition and antioxidant potential of four varieties of Phaseolus vulgaris L. and Glycine max L. LWT. 2019;103:238–246. https://doi.org/10.1016/j.lwt.2019.01.010
65. Xu B, Chang SKC. Effect of soaking, boiling, and steaming on total phenolic contentand antioxidant activities of cool season food legumes. Food Chemistry. 2008;110(1):1–13. https://doi.org/10.1016/j.foodchem.2008.01.045
66. Acito M, Fatigoni C, Villarini M, Moretti M. Effect of cooking and domestic storage on the antioxidant activity of Lenticchia di Castelluccio di Norcia, an Italian PGI lentil landrace. International Journal of Environmental Research and Public Health. 2023;20(3):2585. https://doi.org/10.3390/ijerph20032585
67. Toor BS, Kaur A, Sahota PP, Kaur J. Antioxidant potential, antinutrients, mineral composition and FTIR spectra of legumes fermented with Rhizopus oligosporus. Food Technology and Biotechnology. 2021;59(4):530–542. https://doi.org/10.17113/ftb.59.04.21.7319
68. Tsao R. Chemistry and biochemistry of dietary polyphenols. Nutrients. 2010;2(12):1231–1246. https://doi.org/10.3390/nu2121231
69. Sánchez-Tapia M, Hernández-Velázquez I, Pichardo-Ontiveros E, Granados-Portillo O, Gálvez A, Tovar AR, et al. Consumption of cooked black beans stimulates a cluster of some clostridia class bacteria decreasing inflammatory response and improving insulin sensitivity. Nutrients. 2020;12(4):1182. https://doi.org/10.3390/nu12041182
70. Peng L, Guo F, Pei M, Tsao R, Wang X, Jiang L, et al. Anti-inflammatory effect of lentil hull (Lens culinaris) extract via MAPK/NF-κB signaling pathways and effects of digestive products on intestinal barrier and inflammation in Caco-2 and Raw264.7 co-culture. Journal of Functional Foods. 2022;92:105044. https://doi.org/10.1016/j.jff.2022.105044
71. Rivera-Jiménez J, Berraquero-García C, Pérez-Gálvez R, García-Moreno PJ, Espejo-Carpio FJ, Guadix A, et al. Peptides and protein hydrolysates exhibiting anti-inflammatory activity: Sources, structural features and modulation mechanisms. Food and Function. 2022;13(24):12510–12540. https://doi.org/10.1039/D2FO02223K