Аннотация

Lycopene and other carotenoids have a significant added value in the food and cosmetic industries due to their nutraceutical properties and antioxidant activity. The extraction and stabilization of these compounds remain challenging due to their sensitivity to light, temperature fluctuations, and oxidation. This article introduces a sustainable method of extracting lycopene from tomato waste (Solanum lycopersicum L.) using layered double hydroxide nanoparticles to stabilize lycopene. We used tomato juice and lycopene as a positive control, while ZnAl was a negative control. The experimental samples included 75 and 100 mg of zinc salt per 1 mL of tomato juice, which were labeled as ZnAl75J and ZnAl100J. Zinc and aluminum salts developed insoluble hydroxides, which precipitated lycopene from tomato juice, thus forming composites. The composites proved to be efficient means of encapsulating lycopene as they recovered 97% lycopene present in tomato juice. The physicochemical properties of the organic material enhanced resistance to thermal degradation and acted as an extended-release antioxidant. ZnAl100J, which contained a lot of lycopene, inhibited 89% of DPPH• in 24 h and showed a value higher than IC50 for ABTS•+, which was 0.02 μg/mL of TEAC ABTS•+. ZnAl75J composites showed a higher protection against oxidation and a higher sun protection factor value (3.08) at 15% concentration. The composites could be used as an active ingredient in a wide range of formulations that require antioxidant and photosensitizing properties, or simply as encapsulators and carriers of lycopene.

Ключевые слова

Lycopene, composites, hydroxides, zinc salts, aluminum salts, layered nanoparticles, antioxidant activity

ФИНАНСИРОВАНИЕ

This research was supported by the National Council for Humanities, Sciences, and Technologies (CONAHCYT), México, due to the doctoral scholarship given to Rosa Nallely Murillo Vázquez (CVU number: 486681).

СПИСОК ЛИТЕРАТУРЫ

1. Heriyanto S, Romulo A. Tomato pomace ketchup: Physicochemical, microbiological, and sensory characteristics. Food Processing: Techniques and Technology. 2023;53(4):766–774. https://doi.org/10.21603/2074-9414-2023-4-2477
2. Madia VN, de Vita D, Ialongo D, Tudino V, de Leo A, Scipione L, et al. Recent advances in recovery of lycopene from tomato waste: A potent antioxidant with endless benefits. Molecules. 2021;26(15):4495. https://doi.org/10.3390/molecules26154495
3. Méndez-Carmona JY, Ascacio-Valdes JA, Alvarez-Perez OB, Hernández-Almanza AY, Ramírez-Guzman N, Sepúlveda L, et al. Tomato waste as a bioresource for lycopene extraction using emerging technologies. Food Bioscience. 2022;49:101966. https://doi.org/10.1016/j.fbio.2022.101966
4. Yasmeen N, Sameer AS, Nissar S. Lycopene. In: Kour J, Nayik GA, editors. Nutraceuticals and health care. Academic Press; 2022. pp. 115–134. https://doi.org/10.1016/B978-0-323-89779-2.00009-0
5. Hernández DE, Magallon AP, Arizaga GGC. Green extraction of lycopene from tomato juice with layered double hydroxide nanoparticles. Micro and Nano Letters. 2019;14(3):230–233. https://doi.org/10.1049/mnl.2018.5437
6. Chen Z, Fan Q, Huang M, Cölfen H. Synthesis of two-dimensional layered double hydroxides: A systematic overview. CrystEngComm. 2022;24(26):4639–4655. https://doi.org/10.1039/D2CE00511E
7. Min L, Duan J, Song C, Chen Y, Zhang W, Wang Y. Decarbonating layered double hydroxides using a carbonated salt solution. Dalton Transactions. 2023;52(21):7330–7335. https://doi.org/10.1039/D3DT01079A
8. Kesavan Pillai S, Kleyi P, de Beer M, Mudaly P. Layered double hydroxides: An advanced encapsulation and delivery system for cosmetic ingredients – An overview. Applied Clay Science. 2020;199:105868. https://doi.org/10.1016/j.clay.2020.105868
9. Mosangi D, Moyo L, Kesavan Pillai S, Ray SS. Acetyl salicylic acid-ZnAl layered double hydroxide functional nanohybrid for skin care application. RSC Advances. 2016;6(107):105862–105870. https://doi.org/10.1039/C6RA22172F
10. Cheng H-M, Gao X-W, Zhang K, Wang X-R, Zhou W, Li S-J, et al. A novel antimicrobial composite: ZnAl-hydrotalcite with p-hydroxybenzoic acid intercalation and its possible application as a food packaging material. New Journal of Chemistry. 2019;43(48):19408–19414. https://doi.org/10.1039/C9NJ03943K
11. Egambaram OP, Kesavan Pillai S, Ray SS, Goosen M. Structural and photoprotective characteristics of Zn-Ti, Zn-Al, and Mg-Al layered double hydroxides – A comparative study. Cosmetics. 2023;10(4):100. https://doi.org/10.3390/cosmetics10040100
12. Szerlauth A, Muráth S, Szilagyi I. Layered double hydroxide-based antioxidant dispersions with high colloidal and functional stability. Soft Matter. 2020;16(46):10518–10527. https://doi.org/10.1039/D0SM01531H
13. Singh A, Ahmad S, Ahmad A. Green extraction methods and environmental applications of carotenoids – A review. RSC Advances. 2015;5(77):62358–62393. https://doi.org/10.1039/C5RA10243J
14. Ma Y, Zhong L, Peng Z, Liu X, Ouyang D, Guan S. Development of a highly water-soluble lycopene cyclodextrin ternary formulation by the integrated experimental and modeling techniques. AAPS PharmSciTech. 2021;22:5. https://doi.org/10.1208/s12249-020-01861-
15. Aghel N, Ramezani Z, Amirfakhrian S. Isolation and quantification of lycopene from tomato cultivated in Dezfoul, Iran. Jundishapur Journal of Natural Pharmaceutical Products. 2011;6(1):9–15.
16. Benítez JJ, Castillo PM, del Río JC, León-Camacho M, Domínguez E, Heredia A, et al. Valorization of tomato processing by-products: Fatty acid extraction and production of bio-based materials. Materials. 2018;11(11):2211. https://doi.org/10.3390/ma11112211
17. Gordeeva A, Hsu Y-J, Jenei IZ, Brant Carvalho PHB, Simak SI, Andersson O, et al. Layered zinc hydroxide dihydrate, Zn5(OH)10·2H2O, from hydrothermal conversion of ε-Zn(OH)2 at gigapascal pressures and its transformation to nanocrystalline ZnO. ACS Omega. 2020;5(28):17617–17627. https://doi.org/10.1021/acsomega.0c02075
18. Bastianini M, Faffa C, Sisani M, Petracci A. Caffeic acid-layered double hydroxide hybrid: A new raw material for cosmetic applications. Cosmetics. 2018;5(3):51. https://doi.org/10.3390/cosmetics5030051
19. Bukhtiyarova MV. A review on effect of synthesis conditions on the formation of layered double hydroxides. Journal of Solid State Chemistry. 2019;269:494–506. https://doi.org/10.1016/j.jssc.2018.10.018
20. Wang T, Jin B, Jiao Z, Lu G, Ye J, Bi Y. Photo-directed growth of Au nanowires on ZnO arrays for enhancing photoelectrochemical performances. Journal of Materials Chemistry A. 2014;2(37):15553–15559. https://doi.org/10.1039/C4TA02960G
21. Chen H, Deng H, Zhong X, Zhou H, Zhan J, Zhou X. Highly dispersed amorphous ZnO on a petal-like porous silica-clay composite with enhanced antimicrobial properties. Colloids and Surfaces B: Biointerfaces. 2022;220:112978. https://doi.org/10.1016/j.colsurfb.2022.112978
22. Xiao S, Zhao L, Leng X, Lang X, Lian J. Synthesis of amorphous TiO2 modified ZnO nanorod film with enhanced photocatalytic properties. Applied Surface Science. 2014;299:97–104. https://doi.org/10.1016/j.apsusc.2014.01.192
23. Naumkin AV, Kraut-Vass A, Gaarenstroom SW, Powell CJ. NIST X-ray photoelectron spectroscopy database. Gaithersburg: National Institute of Standards and Technology; 2000. https://doi.org/10.18434/T4T88K
24. Rotole JA, Sherwood PMA. Nordstrandite (Al(OH)3) by XPS. Surface Science Spectra. 1998;5:32–38. https://doi.org/10.1116/1.1247854
25. Pooresmaeil M, Behzadi Nia S, Namazi H. Green encapsulation of LDH(Zn/Al)-5-Fu with carboxymethyl cellulose biopolymer; new nanovehicle for oral colorectal cancer treatment. International Journal of Biological Macromolecules. 2019;139:994–1001. https://doi.org/10.1016/j.ijbiomac.2019.08.060
26. Zhang Y, Chang J, Zhao J, Fang Y. Nanostructural characterization of Al(OH)3 formed during the hydration of calcium sulfoaluminate cement. Journal of the American Ceramic Society. 2018;101(9):4262–4274. https://doi.org/10.1111/jace.15536
27. Guo X, Tang M, Wang N, Li L, Wu Y, Chen X, et al. The synthesis of organically modified layered double hydroxide and its effect on the structure and physical properties of low-density polyethylene/ethylene–vinyl acetate blends. Polymers and Polymer Composites. 2019;27(5):287–298. https://doi.org/10.1177/0967391119846218
28. Adriany A, Jéssica S, Ana O, Raimunda S, Andreanne V, Luan S, et al. Anti-inflammatory and antioxidant activity improvement of lycopene from guava on nanoemulsifying system. Journal of Dispersion Science and Technology. 2021;42(5):760–770. https://doi.org/10.1080/01932691.2020.1728300
29. Cámara M, de Cortes Sánchez-Mata M, Fernández-Ruiz V, Cámara RM, Manzoor S, Caceres JO. Lycopene: A review of chemical and biological activity related to beneficial health effects. Studies in Natural Products Chemistry. 2013;40:383–426. https://doi.org/10.1016/B978-0-444-59603-1.00011-4
30. Guerra AS, Hoyos CG, Molina-Ramírez C, Velásquez-Cock J, Vélez L, Gañán P, et al. Extraction and preservation of lycopene: A review of the advancements offered by the value chain of nanotechnology. Trends in Food Science and Technology. 2021;116:1120–1140. https://doi.org/10.1016/j.tifs.2021.09.009
31. Zhang C, Li C, Zhu Y, Cui H, Lin L. Stability of a novel glycosylated peanut protein isolate delivery system loaded with gallic acid. Food Chemistry. 2024;437:137790. https://doi.org/10.1016/j.foodchem.2023.137790
32. Joshi H, Hegde AR, Shetty PK, Gollavilli H, Managuli RS, Kalthur G, et al. Sunscreen creams containing naringenin nanoparticles: Formulation development and in vitro and in vivo evaluations. Photodermatology Photoimmunology and Photomedicine. 2018;34(1):69–81. https://doi.org/10.1111/phpp.12335
33. Aloanis AA, Karundeng M, Paat VI, Tengker SMT, Siwu O. Sun protecting factor value of the Ficus benjamina Linn. fruits extract. Journal of Physics: Conference Series. 2021;1968:012009. https://doi.org/10.1088/1742-6596/1968/1/012009
34. Rohmah J, Wulandari FE, Rini CS. In vitro: Sunscreen activity of red lettuce extract (Lactuca sativa var. crispa L.). IOP Conference Series: Earth and Environmental Science. 2020;519:012009. https://doi.org/10.1088/1755-1315/519/1/012009
35. Fogaça LA, Feuser PE, Ricci-Júnior E, Hermes de Araújo PH, Sayer C, da Costa C. ZnO and quercetin encapsulated nanoparticles for sun protection obtained by miniemulsion polymerization using alternative co-stabilizers. Materials Research Express. 2020;7:015096. https://doi.org/10.1088/2053-1591/ab6c8e
36. Lademann J, Meinke M, Sterry W, Darvin M. Carotenoids in human skin. Experimental Dermatology. 2011;20:377–382. https://doi.org/10.1111/j.1600-0625.2010.01189.x
37. Low LE, Siva SP, Ho YK, Chan ES, Tey BT. Recent advances of characterization techniques for the formation, physical properties and stability of Pickering emulsion. Advances in Colloid and Interface Science. 2020;277:102117. https://doi.org/10.1016/j.cis.2020.102117