Walailak University, Nakhon Si Thammarat, Таиланд
Walailak University, Nakhon Si Thammarat, Таиланд
Walailak University, Nakhon Si Thammarat, Таиланд
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Sattayakhom A, Koomhin P, Matan N. Prospects for developing sleep-related functional foods: Use of electroencephalography for objective sleep measurement. Foods and Raw Materials. 2027;15(2):392–410.
https://doi.org/10.21603/2308-4057-2027-2-716
This work was financially supported by the Research Center of Excellence in Innovation of Essential Oils and Bioactive Compounds, Walailak University, and partially supported by the National Research Council of Thailand (NRCT) and Walailak University (Grant No. N41A640166).
Abstract
The development of sleep-enhancing food products can improve sleep quality. Understanding the relationship between food consumption and sleep is essential for selecting suitable ingredients for these products.
Electroencephalography is a valuable tool for identifying foods and raw materials used in sleep-promoting products, providing critical insights into their effectiveness.
This review examined the relationship between food consumption and sleep based on research from 2004 to 2024 utilizing electroencephalography tools in human and animal models. The effects of food intake on sleep were examined during the initial stage, slow-wave sleep, and the subsequent stage, rapid eye movement, with measurable parameters recorded. The intake quantity and concentration of specific foods or ingredients were analyzed in human and animal models, considering both normal sleep patterns and sleep disorder models. The analysis revealed that foods associated with sleep, as determined by electroencephalography testing, can be classified into six categories: essential oils, Chinese herbal medicines, plant and fungi extracts, tea and cocoa, probiotics and prebiotics in fermented foods, and food supplements.
All the food types predominantly influenced the initial stage of sleep, specifically slow-wave sleep during non-rapid eye movement. In contrast, foods containing Chinese herbal medicines or extracts demonstrated a significant effect on the rapid eye movement stage. These findings provide valuable insights into the development of functional foods aimed at improving sleep quality.
Keywords
Sleep monitoring,
slow-wave sleep,
rapid eye movement sleep,
sleep-enhancing food products,
functional food development,
sleep quality
References
-
Brinkman JE, Reddy V, Sharma S. Physiology of Sleep. StatPearls. Treasure Island: StatPearls Publishing; 2025.
-
Berry R, Brooks R, Gamaldo C, Harding SM, Lloyd RM, et al. AASM Scoring Manual Updates for 2017 (Version 2.4). Journal of Clinical Sleep Medicine. 2017;13:665–666.
-
Kryger MH, Roth T, Dement WC. Principles and practice of sleep medicine. 5th ed. Philadelphia: Elsevier Health Sciences; 2010, 1766 p.
-
Van de Water ATM, Holmes A, Hurley DA. Objective measurements of sleep for non‐laboratory settings as alternatives to polysomnography – a systematic review. Journal of Sleep Research. 2011;20(1pt2):183–200. https://doi.org/10.1111/j.1365-2869.2009.00814.x
-
Fisher SP, Godinho SI, Pothecary CA, Hankins MW, Foster RG, et al. Rapid assessment of sleep-wake behavior in mice. Journal of biological rhythms. 2012;27(1):48–58. https://doi.org/10.1177/0748730411431550
-
Park KS, Choi SH. Smart technologies toward sleep monitoring at home. Biomedical Engineering Letters. 2019;9:73–85. https://doi.org/10.1007/s13534-018-0091-2
-
Boulos MI, Jairam T, Kendzerska T, Im J, Mekhael A, et al. Normal polysomnography parameters in healthy adults: A systematic review and meta-analysis. The Lancet Respiratory Medicine. 2019;7(6):533–543. https://doi.org/10.1016/S2213-2600(19)30057-8
-
Hagan JJ, Leslie RA, Patel S, Evans ML, Wattam TA, et al. Orexin A activates locus coeruleus cell firing and increases arousal in the rat. Proceedings of the National Academy of Sciences. 1999;96(19):10911–10916. https://doi.org/10.1073/pnas.96.19.10911
-
Saito YC, Tsujino N, Abe M, Yamazaki M, Sakimura K, et al. Serotonergic input to orexin neurons plays a role in maintaining wakefulness and REM sleep architecture. Frontiers in Neuroscience. 2018;12:892. https://doi.org/10.3389/fnins.2018.00892
-
Arrigoni E, Fuller PM. The sleep-promoting ventrolateral preoptic nucleus: What have we learned over the past 25 years? International Journal of Molecular Sciences. 2022;23(6):2905. https://doi.org/10.3390/ijms23062905
-
Deurveilher S, Burns J, Semba K. Indirect projections from the suprachiasmatic nucleus to the ventrolateral preoptic nucleus: A dual tract‐tracing study in rat. European Journal of Neuroscience. 2002;16(7):1195–1213. https://doi.org/10.1046/j.1460-9568.2002.02196.x
-
Yamatsu A, Yamashita Y, Maru I, Yang J, Tatsuzaki J, et al. The improvement of sleep by oral intake of GABA and Apocynum venetum leaf extract. Journal of Nutritional Science and Vitaminology. 2015;61(2):182–187. https://doi.org/10.3177/jnsv.61.182
-
Kim S, Jo K, Hong KB, Han SH, Suh HJ. GABA and L-theanine mixture decreases sleep latency and improves NREM sleep. Pharmaceutical Biology. 2019;57(1):64–72. https://doi.org/10.1080/13880209.2018.1557698
-
Park CW, Hong KB, Suh HJ, Ahn Y. Sleep-promoting activity of amylase-treated Ashwagandha (Withania somnifera L. Dunal) root extract via GABA receptors. Journal of Food and Drug Analysis. 2023;31(2):278–288. https://doi.org/10.38212/2224-6614.3456
-
Nakamura Y, Midorikawa T, Monoi N, Kimura E, Murata-Matsuno A, et al. Oral administration of Japanese sake yeast (Saccharomyces cerevisiae sake) promotes non-rapid eye movement sleep in mice via adenosine A2A receptors. Journal of Sleep Research. 2016;25(6):746–753. https://doi.org/10.1111/jsr.12434
-
Ochoa-de la Paz LD, Gulias-Cañizo R, Ruíz-Leyja ED, Sánchez-Castillo H, Parodí J. The role of GABA neurotransmitter in the human central nervous system, physiology, and pathophysiology. Revista mexicana de neurociencia. 2021;22(2):67–76. https://doi.org/10.24875/rmn.20000050
-
Kim M, Kim YJ, Lee HW, Jung JC, Oh S. Chrysanthemum morifolium and its bioactive substance enhanced the sleep quality in rodent models via Cl− Channel Activation. Nutrients. 2023;15(6):1309. https://doi.org/10.3390/nu15061309
-
Kim D, Yoon M, Kim S, Um MY, Cho S. Effects of green kiwifruit peel extract on sleep-wake profiles in mice: A polysomnographic study based on electroencephalogram and electromyogram recordings. Nutrients. 2022;14(22):4732. https://doi.org/10.3390/nu14224732
-
Al-Sarraf H. Transport of 14C-γ-aminobutyric acid into brain, cerebrospinal fluid and choroid plexus in neonatal and adult rats. Developmental Brain Research. 2002;139(2):121–129. https://doi.org/10.1016/S0165-3806(02)00537-0
-
Basheer R, Strecker RE, Thakkar MM, McCarley RW. Adenosine and sleep–wake regulation. Progress in neurobiology. 2004;73(6):379–396. https://doi.org/10.1016/j.pneurobio.2004.06.004
-
Satoh S, Matsumura H, Hayaishi O. Involvement of adenosine A2A receptor in sleep promotion. European Journal of Pharmacology. 1998;351(2):155–162. https://doi.org/10.1016/S0014-2999(98)00302-1
-
Baba Y, Takihara T, Okamura N. Theanine maintains sleep quality in healthy young women by suppressing the increase in caffeine-induced wakefulness after sleep onset. Food and Function. 2023;14(15):7109–7116. https://doi.org/10.1039/d3fo01247f
-
Nakagawa M, Yamamoto H, Kawaji M, Miura N, Wakame K, et al. Effects of lactic acid bacteria-containing foods on the quality of sleep: A placebo-controlled, double-blinded, randomized crossover study. Functional Foods in Health and Disease. 2018;8(12):579–596. https://doi.org/10.31989/ffhd.v8i12.572
-
Koomhin P, Sattayakhom A, Chandharakool S, Sinlapasorn J, Suanjan S, et al. Michelia essential oil inhalation increases fast alpha wave activity. Scientia Pharmaceutica. 2020;88(2):23. https://doi.org/10.3390/scipharm88020023
-
Chandharakool S, Koomhin P, Sinlapasorn J, Suanjan S, Phungsai J, et al. Effects of tangerine essential oil on brain waves, moods, and sleep onset latency. Molecules. 2020;25(20):4865. https://doi.org/10.3390/molecules25204865
-
Kwangjai J, Cheaha D, Manor R, Sa-ih N, Samerphob N, et al. Modification of brain waves and sleep parameters by Citrus reticulata Blanco. cv. Sai-Nam-Phueng essential oil. Biomedical Journal. 2021;44(6):727–738. https://doi.org/10.1016/j.bj.2020.05.017
-
Ko LW, Su CH, Yang MH, Liu SY, Su TP. A pilot study on essential oil aroma stimulation for enhancing slow-wave EEG in sleeping brain. Scientific Reports. 2021;11:1078. https://doi.org/10.1038/s41598-020-80171-x
-
Cheaha D, Basor N, Sa-i N, Kumarnsit E, Chaikul A, et al. Jasmine essential oil promotes delta-beta power activities in the dorsal hippocampus under slow wave sleep promotion. Songklanakarin Journal of Science and Technology. 2023;45(1):1–10.
-
Sinthupachee A, Koomhin P, Udenigwe CC, Matan N. Active protein ingredient from smoke-dried fish hydrolysates with Litsea cubeba vapor for enhancing organoleptic properties, microbial safety, and brain response. ES Food & Agroforestry. 2024;18:1284. https://doi.org/10.30919/esfaf1284
-
Cheaha D, Issuriya A, Manor R, Kwangjai J, Rujiralai T, et al. Modification of sleep-waking and electroencephalogram induced by vetiver essential oil inhalation. Journal of Intercultural Ethnopharmacology. 2016;5(1):72–78. https://doi.org/10.5455/jice.20160208050736
-
Zhou L, Zhu LY, Zhou W, Zhou YQ, Hu PY, et al. Discussion on safety and related pharmacological mechanism of compound anshen essential oil in relieving sleep disorders. Chinese Pharmacological Bulletin. 2023;39(3):580–587. (In Chinese) https://doi.org/10.12360/CPB202206034
-
Wei Q, Ta G, He W, Wang W, Wu Q. Stilbene glucoside, a putative sleep promoting constituent from Polygonum multiflorum affects sleep homeostasis by affecting the activities of lactate dehydrogenase and salivary alpha amylase. Chemical and Pharmaceutical Bulletin. 2017;65(11):1011–1019. https://doi.org/10.1248/cpb.c17-00275
-
Woo JH, Ha TW, Kang JS, Hong JT, Oh KW. Potentiation of decursinol angelate on pentobarbital-induced sleeping behaviors via the activation of GABAA-ergic systems in rodents. Korean Journal of Physiology & Pharmacology. 2017;21(1):27–36. https://doi.org/10.4196/kjpp.2017.21.1.27
-
Kwon YO, Hong JT, Oh KW. Rosmarinic acid potentiates pentobarbital-induced sleep behaviors and non-rapid eye movement (NREM) sleep through the activation of GABAA-ergic systems. Biomolecules & Therapeutics. 2017;25(2):105–111. https://doi.org/10.4062/biomolther.2016.035
-
Yoo JH, Ha TW, Hong JT, Oh KW. Sinomenine, an alkaloid derived from Sinomenium acutum potentiates pentobarbital-induced sleep behaviors and non-rapid eye movement (NREM) sleep in rodents. Biomolecules & Therapeutics. 2017;25(6):586–592. https://doi.org/10.4062/biomolther.2017.157
-
Yoon M, Cho S. Triphlorethol A, a dietary polyphenol from seaweed, decreases sleep latency and increases non-rapid eye movement sleep in mice. Marine Drugs. 2018;16(5):139. https://doi.org/10.3390/md16050139
-
Lin S, Nie B, Song K, Ye R, Yuan Z. Pinelliae rhizoma praeparatum cum alumine extract: Sedative and hypnotic effects in mice and component compounds. BioMed Research International. 2019;2019:6198067. https://doi.org/10.1155/2019/6198067
-
Murthy SV, Fathima SN, Mote R. Hydroalcoholic extract of Ashwagandha improves sleep by modulating GABA/histamine receptors and EEG slow-wave pattern in in vitro – in vivo experimental models. Preventive Nutrition and Food Science. 2022;27(1):108–120. https://doi.org/10.3746/pnf.2022.27.1.108
-
Miyazaki K, Itoh N, Saiki P, Kuroki Y. Supplementation with Eurycoma longifolia extract modulates diurnal body temperature fluctuation and sleep rhythm in mice. Journal of Nutritional Science and Vitaminology. 2022;68(4):342–347. https://doi.org/10.3177/jnsv.68.342
-
Choi JJ, Oh EH, Lee MK, Chung YB, Hong JT, et al. Gastrodiae rhizoma ethanol extract enhances pentobarbital-induced sleeping behaviors and rapid eye movement sleep via the activation of GABAA-ergic transmission in rodents. Evidence-based Complementary and Alternative Medicine. 2014;2014:426843. https://doi.org/10.1155/2014/426843
-
Hua R, Ding Y, Liu X, Niu B, Chen X, et al. Lonicerae Japonicae Flos extract promotes sleep in sleep-deprived and lipopolysaccharide-challenged mice. Frontiers in Neuroscience. 2022;16:848588. https://doi.org/10.3389/fnins.2022.848588
-
Abdollahnejad F, Mosaddegh M, Nasoohi S, Mirnajafi-Zadeh J, Kamalinejad M, et al. Study of sedative-hypnotic effects of Aloe vera L. aqueous extract through behavioral evaluations and EEG recording in rats. Iranian Journal of Pharmaceutical Research. 2016;15(1):293–300.
-
Yamashiro K, Aoki M, Matsumoto N, Ikegaya Y. Polyherbal formulation enhancing cerebral slow waves in sleeping rats. Biological and Pharmaceutical Bulletin. 2020;43(9):1356–1360. https://doi.org/10.1248/bpb.b20-00285
-
Martinez-Mota L, Cruz-Tavera A, Dorantes-Barrón AM, Arrieta-Báez D, Ramírez-Salado I, et al. Calea zacatechichi Schltdl. (Compositae) produces anxiolytic- and antidepressant-like effects, and increases the hippocampal activity during REM sleep in rodents. Journal of Ethnopharmacology. 2021;265:113316. https://doi.org/10.1016/j.jep.2020.113316
-
Takeda R, Yamamoto K, Tokuda M, Koga J, Higaki M, et al. Improvement in quality of sleep by the intake of saffron–derived crocin and safranal – a randomized, double–blind, placebo–controlled, parallel–group trial–. Japanese Pharmacology and Therapeutics. 2020;48(3):497–504. (In Japanese)
-
Ahn Y, Kim S, Park C, Kim JE, Suh HJ, et al. Sleep-promoting activity of lotus (Nelumbo nucifera) rhizome water extract via GABAA receptors. Pharmaceutical Biology. 2022;60(1):1341–1348. https://doi.org/10.1080/13880209.2022.2096076
-
Kim S, Hong KB, Jo K, Suh HJ. Quercetin-3-O-glucuronide in the ethanol extract of lotus leaf (Nelumbo nucifera) enhances sleep quantity and quality in a rodent model via a GABAergic mechanism. Molecules. 2021;26(10):3023. https://doi.org/10.3390/molecules26103023
-
Kwon YO, Ha TW, Oh KW. Ethanol extract of Perillae herba enhances pentobarbital-induced sleep and non-rapid eye movement (NREM) sleep through GABAA-ergic systems. Natural Product Sciences. 2017;23(1):53–60. https://doi.org/10.20307/nps.2017.23.1.53
-
Ahn Y, Lee HH, Kim BH, Park SJ, Kim YS, et al. Heukharang lettuce (Lactuca sativa L.) leaf extract displays sleep-promoting effects through GABAA receptor. Journal of Ethnopharmacology. 2023;314:116602. https://doi.org/10.1016/j.jep.2023.116602
-
Hong KB, Han SH, Park Y, Suh HJ, Choi HS. Romaine lettuce/skullcap mixture improves sleep behavior in vertebrate models. Biological and Pharmaceutical Bulletin. 2018;41(8):1269–1276. https://doi.org/10.1248/bpb.b18-00267
-
Jo K, Kim S, Ahn Y, Suh HJ. Effects of green lettuce leaf extract on sleep disturbance control in oxidative stress-induced invertebrate and vertebrate models. Antioxidants. 2021;10(6):970. https://doi.org/10.3390/antiox10060970
-
Kim HW, Suh HJ, Choi HS, Hong KB, Jo K. Effectiveness of the sleep enhancement by green romaine lettuce (Lactuca sativa) in a rodent model. Biological and Pharmaceutical Bulletin. 2019;42(10):1726–1732. https://doi.org/10.1248/bpb.b19-00454
-
Rahimi S, Alaei H, Reisi P, Zarrin B, Siahmard Z, et al. Hydroalcoholic Tarooneh extract (spathe of phoenix dactylifera) increased sedative-hypnotic effects and modulated electroencephalography brain waves in Anesthetized Rats. Advanced Biomedical Research. 2019;8(1):24. https://doi.org/10.4103/abr.abr_58_16
-
Yoon M, Kim JS, Jo J, Han D, Cho S. Sleep-promoting effect of Ecklonia cava: Ethanol extract promotes non-rapid eye movement sleep in C57BL/6N mice. Fisheries and Aquatic Sciences. 2014;17(1):19–25. https://doi.org/10.5657/FAS.2014.0019
-
Li IC, Lin TW, Lee TY, Lo Y, Jiang YM, et al. Oral administration of Armillaria mellea mycelia promotes non-rapid eye movement and rapid eye movement sleep in rats. Journal of Fungi. 2021;7(5):371. https://doi.org/10.3390/jof7050371
-
Li TJ, Lee TY, Lo Y, Lee LY, Li IC, et al. Hericium erinaceus mycelium ameliorate anxiety induced by continuous sleep disturbance in vivo. BMC Complementary Medicine and Therapies. 2021;21:295. https://doi.org/10.1186/s12906-021-03463-3
-
Kim H, Park I, Park K, Park S, Kim YI, et al. The positive effects of Poria cocos extract on quality of sleep in insomnia rat models. International Journal of Environmental Research and Public Health. 2022;19(11):6629. https://doi.org/10.3390/ijerph19116629
-
Uchida M, Suzuki M, Shimizu K. Mycelial extract of cultured cordyceps sinensis improves the sleep disturbance induced by placing rats on the grid suspended over water. Japanese Pharmacology and Therapeutics. 2016;44(6):881–885.
-
Panagiotou M, Meijer M, Meijer JH, Deboer T. Effects of chronic caffeine consumption on sleep and the sleep electroencephalogram in mice. Journal of Psychopharmacology. 2019;33(1):122–131. https://doi.org/10.1177/0269881118806300
-
Kim D, Kim S, Yoon M, Um MY, Cho S. Effects of chronic administration of green tea ethanol extract on sleep architecture in mice: A comparative study with a representative stimulant caffeine. Nutrients. 2023;15(4):1042. https://doi.org/10.3390/nu15041042
-
Kwon S, Yoon M, Lee J, Moon KD, Kim D, et al. A standardized phlorotannin supplement attenuates caffeine-induced sleep disruption in mice. Nutrients. 2019;11(3):556. https://doi.org/10.3390/nu11030556
-
Oishi K, Okauchi H, Yamamoto S, Higo-Yamamoto S. Dietary natural cocoa ameliorates disrupted circadian rhythms in locomotor activity and sleep-wake cycles in mice with chronic sleep disorders caused by psychophysiological stress. Nutrition. 2020;75–76:110751. https://doi.org/10.1016/j.nut.2020.110751
-
Miyazaki K, Itoh N, Yamamoto S, Higo-Yamamoto S, Nakakita Y, et al. Dietary heat-killed Lactobacillus brevis SBC8803 promotes voluntary wheel-running and affects sleep rhythms in mice. Life Sciences. 2014;111(1–2):47–52. https://doi.org/10.1016/j.lfs.2014.07.009
-
Thompson RS, Roller R, Mika A, Greenwood BN, Knight R, et al. Dietary prebiotics and bioactive milk fractions improve NREM sleep, enhance REM sleep rebound and attenuate the stress-induced decrease in diurnal temperature and gut microbial alpha diversity. Frontiers in Behavioral Neuroscience. 2016;10:240. https://doi.org/10.3389/fnbeh.2016.00240
-
Higo-Yamamoto S, Yamamoto S, Miyazaki K, Nakakita Y, Kaneda H, et al. Dietary heat-killed Lactobacillus brevis SBC8803 attenuates chronic sleep disorders induced by psychophysiological stress in mice. Journal of Nutritional Science and Vitaminology. 2019;65(2):164–170. https://doi.org/10.3177/jnsv.65.164
-
Monoi N, Matsuno A, Nagamori Y, Kimura E, Nakamura Y, et al. Japanese sake yeast supplementation improves the quality of sleep: A double-blind randomised controlled clinical trial. Journal of Sleep Research. 2016;25(1):116–123. https://doi.org/10.1111/jsr.12336
-
Varin C, Rancillac A, Geoffroy H, Arthaud S, Fort P, et al. Glucose induces slow-wave sleep by exciting the sleep-promoting neurons in the ventrolateral preoptic nucleus: A new link between sleep and metabolism. Journal of Neuroscience. 2015;35(27):9900–9911. https://doi.org/10.1523/jneurosci.0609-15.2015
-
Bae GY, Ahn Y, Hong KB, Jung EJ, Suh HJ, et al. Sleep-enhancing effect of water extract from jujube (Zizyphus jujuba Mill.) seeds fermented by Lactobacillus brevis L32. Foods. 2023;12(15):2864. https://doi.org/10.3390/foods12152864
-
Minet-Ringuet J, Le Ruyet PM, Tomé D, Even PC. A tryptophan-rich protein diet efficiently restores sleep after food deprivation in the rat. Behavioural Brain Research. 2004;152(2):335–340. https://doi.org/10.1016/j.bbr.2003.10.018
-
Halson SL, Shaw G, Versey N, Miller DJ, Sargent C, et al. Optimisation and validation of a nutritional intervention to enhance sleep quality and quantity. Nutrients. 2020;12(9):2579. https://doi.org/10.3390/nu12092579
-
Thiagarajah K, Chee HP, Sit NW. Effect of alpha-S1-casein tryptic hydrolysate and L-theanine on poor sleep quality: A double blind, randomized placebo-controlled crossover trial. Nutrients. 2022;14(3):652. https://doi.org/10.3390/nu14030652
-
Cherasse Y, Saito H, Nagata N, Aritake K, Lazarus M, et al. Zinc-containing yeast extract promotes nonrapid eye movement sleep in mice. Molecular Nutrition and Food Research. 2015;59(10):2087–2093. https://doi.org/10.1002/mnfr.201500082
-
Ye M, Lee S, Yu HJ, Kim KR, Park HJ, et al. Sedative-hypnotic effects of Glycine max merr. extract and its active ingredient genistein on electric-shock-induced sleep disturbances in rats. International Journal of Molecular Sciences. 2023;24(8):7043. https://doi.org/10.3390/ijms24087043
-
Ta QV, Yoon M, Yang H, Kim J, Cho S, et al. Effects of blue mussel (ME) water extracts on pentobarbital-induced sleep and the sleep architecture in mice. Food Science and Biotechnology. 2015;24:295–300. https://doi.org/10.1007/s10068-015-0039-6
-
Nedachi T, Haketa K, Harakawa S, Miura N, Wakame K. Effect of combining sleep-promoting food intake and electric field application on sleep in healthy participants: A pilot study. Functional Foods in Health and Disease 2021;11(12):659–672. https://doi.org/10.31989/ffhd.v11i12.861