ISSN 2308-4057 (Print),
ISSN 2310-9599 (Online)

Antibiotic activity and resistance of lactic acid bacteria and other antagonistic bacteriocin-producing microorganisms

Аннотация
Introduction. Increased resistance of microorganisms to traditional antibiotics has created a practical need for isolating and synthesizing new antibiotics. We aimed to study the antibiotic activity and resistance of bacteriocins produced by lactic acid bacteria and other microorganisms.
Study objects and methods. We studied the isolates of the following microorganism strains: Bacillus subtilis, Penicillium glabrum, Penicillium lagena, Pseudomonas koreenis, Penicillium ochrochloron, Leuconostoc lactis, Lactobacillus plantarum, Leuconostoc mesenteroides, Pediococcus acidilactici, Leuconostoc mesenteroides, Pediococcus pentosaceus, Lactobacillus casei, Lactobacillus fermentum, Bacteroides hypermegas, Bacteroides ruminicola, Pediococcus damnosus, Bacteroides paurosaccharolyticus, Halobacillus profundi, Geobacillus stearothermophilus, and Bacillus caldotenax. Pathogenic test strains included Escherichia coli, Salmonella enterica, Staphylococcus aureus, Pseudomonas aeruginosa, Bacillus mycoides, Alcaligenes faecalis, and Proteus vulgaris. The titer of microorganisms was determined by optical density measurements at 595 nm.
Results and discussion. We found that eleven microorganisms out of twenty showed high antimicrobial activity against all test strains of pathogenic and opportunistic microorganisms. All the Bacteroides strains exhibited little antimicrobial activity against Gramnegative test strains, while Halobacillus profundi had an inhibitory effect on Gram-positive species only. The Penicillium strains also displayed a slight antimicrobial effect on pathogenic test strains.
Conclusion. The antibiotic resistance of the studied lactic acid bacteria and other bacteriocin-producing microorganisms allows for their use in the production of pharmaceutical antibiotic drugs.
Ключевые слова
Lactic acid bacteria , bacteriocins , antibiotic properties , antibiotic resistance , natural sources , isolates
ФИНАНСИРОВАНИЕ
The study was part of the federal targeted program on “Obtaining Pharmaceutical Substances Based on Antagonist Microorganisms Isolated from Natural Sources” (Unique Project Identifier RFMEFI57418X0207) under Agreements No. 075-02-2018-1934 of December 20, 2018 and No. 075-15-2019-1383 of June 18, 2019 of the Ministry of Science and Higher Education of the Russian Federation (Minobrnauka).
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Как цитировать?
Antibiotic activity and resistance of lactic acid bacteria and other antagonistic bacteriocin-producing microorganisms. Foods and Raw Materials, 2020, vol. 8, no. 2, pp. 377-384
DOI
http://doi.org/10.21603/2308-4057-2020-2-377-384
Издатель
Кемеровский государственный университет
htpps://kemsu.ru
ISSN
2308-4057 (Print) /
2310-9599 (Online)
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