Abstract

Diabetes mellitus is the most threatening form of human metabolic disorder and of malnutrution as one of the main causes of its development. The purpose of the studies is the development of a functional basis of phyto- beverages based on herbal medicinal raw materials with a high antioxidant activity for the correction of nutrition for diabetic patients. The object of the studies was plant medicinal raw materials that grow mainly in the territory of the Kemerovo region, various vegetative parts of plants were used: leaves (of cranberry, knotgrass, common St. John's wort, blindweed, common plantain and common horsetail); roots (of elecampane, common burdock, common dandelion); valves (common beans); shoots (of blueberry). The antioxidant activity of water extracts from plant raw materials mixtures was determined using a spectrophotometric method based on the determination of concentration of malonic dialdehyde in biological material. The following compositions of mixtures have been experimentally determined: 1) common St. John's wort, great nettle, common dandelion, blueberry, common horsetail; 2) knotgrass, great nettle, blueberry, common horsetail; as well as the following extraction parameters: the degree of grinding of raw material is 5-8 mm, the ratio of solid (medicinal plant raw material) and liquid (water) phases is 1 : 7, the temperature is 50 ± 1C, the extraction time is 6 hours. A possibility of preserving finished extracts with alcohol up to 8% of the volume fraction has been determined, which allows to keep them for 30 days providing the alcohol content in the beverage on the basis of the extract of not more than 0.5%, according to the applicable requirements. It has been shown that the created extracts have an antioxidant activity.

Keywords

Antioxidant activity, phyto-beverages, diabetes mellitus, nutrition correction

REFERENCES

1. Whiting D.R., Guariguata L., Weil C., and Shaw J. IDF diabetes atlas: global estimates of the prevalence of diabetes for 2011 and 2030. Diabetes Research and Clinical Practice, 2011, vol. 94, no. 3, pp. 311-321. DOI: 10.1016/j.diabres.2011.10.029.
2. IDF atlas (7th edition update). Brussels, Belgium. International Diabetes Federation, 2015. Available at: http://www.diabetesatlas.org/ (accessed 28 April 2017).
3. Dedov I.I., Shestakova M.V., and Galstyan G.R. The prevalence of type 2 diabetes mellitus in the adult population of Russia (NATION study). Diabetes Mellitus, 2016, vol. 19, no. 2, pp. 104-112. DOI: 10.14341/DM2004116-17.
4. Davydenko N.I. and Mayurnikova L.A. On the possibility to grow high-selenium wheat in the Kuznetsk Basin. Food and Raw Materials, 2014, vol. 2, no. 1, pp. 67-81. DOI: 10.12737/4089.
5. Davydenko N.I. The development of a complex additive for bread enrichment with selenium and iodine. Food Processing: Techniques and Technology, 2013, no. 1, pp. 127-132. (In Russian).
6. Kaneto H., Kajimoto Y., Miyagawa J., et al. Beneficial effects of antioxidants in diabetes. Diabetes, 1999, vol. 48, no. 12, pp. 2398-2406.
7. Gromnatsky N.I. Diabetologiya [Diabetology]. Moscow: All-Russian educational, scientific and methodological center for continuing medical and pharmaceutical education of the Ministry of Health of the Russian Federation, 2002. 256 p.
8. Babenkova I.V. and Teselkin Yu.O. Effect of an antioxidant drug based on bioflavonoids and vitamin C on the antioxidant activity of blood plasma. Problems of Nutrition, 1999, no. 3, pp. 9-11. (In Russian).
9. Dadali V.A. and Makarov V.G. Biologicheski aktivnye veshchestva lekarstvennykh rasteniy kak faktor detoksikatsii organizma [Biologically active substances of medicinal plants as a factor of detoxification of organism]. Problems of Nutrition, 2003, no. 5, pp. 49-55. (In Russian).
10. Chanda S. and Dave R. In vitro models for antioxidant activity evaluation and some medicinal plants possessing antioxidant properties: An overview. African Journal of Microbiology Research, 2009, 3(13), pp. 981-96.
11. Sulaiman Mohammed, Tijani Hamzat Ibiyeye, Abubakar Bashir Mohammed, et al. An overview of natural plant antioxidants: analysis and evaluation. African Journal of Microbiology Research, 2013, 1(4), pp. 64-72. DOI: 10.11648/j.ab.20130104.12.
12. Zhu H., Wang Y., Wang J., et al. Antidiabetic and antioxidant effects of catalpol extracted from rehmannia glutinosa (di huang) on rat diabetes induced by streptozotocin and high-fat, high-sugar feed. Chinese medicine, 2016, vol. 11, no. 1, Article number 25. DOI: 10.1186/s13020-016-0096-7.
13. Dzhafarova R.E. Study of action of phytocomplex «Antidiabet» and «Mirfazin» to sugar in blood plasma and glycogen in liver and muscle tissue. Vestnik of Russian military medical Academy, 2013, no. 4(44), pp. 172-174. (In Russian).
14. Chang C.L. and Lin C.S. Phytochemical composition, antioxidant activity, and neuroprotective effect of Terminalia chebula Retzius extracts. Evidence-Based Complementary and Alternative Medicine, vol. 2012. Available at: https://www.hindawi.com/journals/ecam/2012/125247. (accessed 28 December 2016).
15. Abdille Md.H., Singh R.P., Jayaprakasha G.K., and Jena B.S. Antioxidant activity of the extracts from Dillenia indica fruits. Food Chemistry, 2005, vol. 90, no. 4, pp. 891-896. DOI: 10.1016/j.foodchem.2004.09.002.
16. Ma Y., He F.J., Hashem K.M., Macgregor G.A., and Yin Y. Gradual reduction of sugar in soft drinks without substitution as a strategy to reduce overweight, obesity, and type 2 diabetes: a modelling study. The lancet diabetes and endocrinology, 2016, vol. 4, no. 2, pp.105-114. DOI: 10.1016/S2213-8587(15)00477-5.
17. Yracheta J.M., Lanaspa M.A., Le M.T., et al. Diabetes and kidney disease in american indians: potential role of sugar-sweetened beverages. Mayo clinic proceedings, 2015, vol. 90, no. 6, pp. 813-823. DOI: 10.1016/j.mayocp.2015.03.018.
18. Cherevach E.I., Tenkovskaya L.A., and Pankova M.E. The plant antioxidants for simulating non-alcoholic beverages of bio correctional action. Beer and beverages, 2013, no. 4, pp. 70-72. (In Russian).
19. Kiseleva T.F. Optimization of ingredient structure of functional soft drinks. Beer and beverages, 2006, no. 4, pp. 62-63. (In Russian).
20. Peyrat-Maillard M.N., Bonnely S., and Berset C. Determination of the antioxidant activity of phenolic compounds by coulometric detection. Talanta, 2000, vol. 51, pp. 709-716.
21. Roginsky V. and Lissi E.A. Review of methods to determine Chain-breaking antioxidant activity in food. Food Chemistry, 2005, vol. 92, no. 2, pp. 235-254. DOI: 10.1016/j.foodchem.2004.08.004.
22. Yashin A.Ya., Yashin Ya.I., Chernousova N.I., and Pakhomov V.P. Express electro-mechanical method of antioxidant activity of food products. Beer and beverages, 2004, no. 6, pp. 32-36. (In Russian).
23. Vladimirov G.K., Sergunova E.V., Izmailov D.Yu., and Vladimirov Yu.A. Chemiluminescent determination of total antioxidant capacity in medicinal plant material. Bulletin of Russian State Medical University, 2016, no. 2, pp. 65-72. (In Russian).