ISSN 2308-4057 (Print),
ISSN 2310-9599 (Online)

REGULARITIES OF THE DRYING OF LACTULOSE SOLUTIONS

Abstract
The existing patented technologies of the production of lactulose were analyzed, and leading producers were defined. Crystalline lactulose was produced via the spray drying of lactulose solutions with various mass fractions of solids. The principal dependences of the finished product output on the drying temperature, the solution flow rate, the air flow rate generated by an aspirator, and the gas spray rate were studied. The results of analyzing the presented dependences allowed us to determine the optimal mass fraction of solids in a solution for spray drying. The results of studying the quantitative parameters of dry lactulose, including hygroscopicity, particle size, moisture content, and finished product solubility index, were presented
Keywords
lactulose, lactose, drying, solution, temperature, solution flow rate, air flow rate, mass fraction, solubility index
REFERENCES
  1. Gavrilov, G.B., Tekhnologiya membrannykh protsessov pererabotki molochnoi syvorotki i sozdanie produktov s funktsional’nymi svoistvami (Technology of Membrane Whey Processing and Creation of Products with Functional Properties), Moscow: Rossel’khozakademiya, 2006.
  2. Voskuijl, W, de Lorijn, F, Verwijs, W, et al., PEG 3350 (Transipeg) versus lactulose in the treatment of childhood functional constipation: a double blind, randomised, controlled, multicentre trial, Gut, 2004, vol. 53, no. 11, pp. 1590‒1594.
  3. Petuely, F., Bifidusflora bei Flaschenkindern durch bifidogene Substanzen (Bifidusfactor), Z. Kinderheimkd, 1957, vol. 79, no. 2, pp.174‒179.
  4. Shukla, S., Shukla, A., Mehboob, S., and Guha, S., Meta-analysis: the effects of gut flora modulation using prebiotics, probiotics and synbiotics on minimal hepatic encephalopathy, Alimentary Pharmacology & Therapeutics, 2011, vol. 33, no. 6, pp. 662‒671.
  5. Khramtsov, A.G., Brykalov, B.A., and Kharitonov, D.V., Lactuloza: tsennost’, ispol’zovanie, marketing i effektivnost’ proizvodstva (Lactulose: Value, Application, Marketing, and Production Efficiency), Stavropol: Argus, 2004.
  6. US Patent 41 422 916, 1979.
  7. Jpn. Patent 52-21 063, 1972.
  8. FRG Patent 2 224 680, 1972.
  9. US Patent 3 716 408, 1971.
  10. Jpn. Patent 56-39 200, 1981.
  11. US Patent 4 605 646, 1986.
  12. US Patent 5 644 050, 1993.
  13. US Patent 5 415 695, 1988.
  14. US Patent 5 480 491, 1993.
  15. US Patent 5 688 521, 1994.
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Contents
Abstract
Keywords
References