Autonomous University of the State of Hidalgo, Pachuca
Autonomous University of the State of Hidalgo, Pachuca
Autonomous University of the State of Hidalgo, Pachuca
Autonomous University of the State of Hidalgo, Pachuca
Autonomous University of the State of Hidalgo, Pachuca
Autonomous University of the State of Hidalgo, Pachuca
Autonomous University of the State of Hidalgo, Pachuca
Autonomous University of the State of Hidalgo, Pachuca
Abstract
The increasing demand for natural antimicrobial agents in food preservation has led to a growing interest in Hibiscus sabdariffa L. due to its antimicrobial properties. We conducted a bibliometric analysis to assess the scientific production of antimicrobial extracts and compounds from H. sabdariffa, identifying research trends, relevant applications in the food industry, and knowledge gaps. A structured search was performed in the Web of Science database, retrieving articles published between 1984 and 2025. Bibliometric indicators, including annual publication trends, most influential journals, research collaboration networks, and keyword co-occurrence, were analyzed using R and VOSviewer. The results indicated a yearly growth rate of 8.15% in H. sabdariffa antimicrobial research, with significant contributions from Mexico, Egypt, and India. Studies have demonstrated that H. sabdariffa extracts, particularly ethanolic and aqueous fractions, exhibit potent antibacterial activity against Escherichia coli, Listeria monocytogenes, and Staphylococcus aureus, attributed to phenolic compounds, flavonoids, and anthocyanins. Despite promising applications, challenges remain regarding the stability of H. sabdariffa compounds in food matrices, standardization of extraction methods, and regulatory approval for commercialization. Future research should optimize extraction techniques, develop nanoencapsulation strategies to enhance stability, and explore synergistic effects with other natural antimicrobials. Additionally, interdisciplinary studies combining food science, pharmacology, and biotechnology could further elucidate H. sabdariffa’s antimicrobial mechanisms and facilitate its integration into sustainable food preservation systems. This analysis provides valuable insights into the current research landscape and outlines strategic directions for advancing the application of H. sabdariffa-based antimicrobials in the food industry.
Keywords
Antimicrobial properties,
phenolics,
extraction standardization,
natural food preservatives,
encapsulated bioactives,
shelf-life extension
References
- Nguyen QV, Chuyen HV. Processing of herbal tea from roselle (Hibiscus sabdariffa L.): Effects of drying temperature and brewing conditions on total soluble solid, phenolic content, antioxidant capacity and sensory quality. Beverages. 2020;6(1):2. https://doi.org/10.3390/beverages6010002
- Paim MP, Maciel MJ, Weschenfelder S, Bergmann GP, Avancini CAM. Anti-Escherichia coli effect of Hibiscus sabdariffa L. in a meat model. Food Science and Technology. 2017;37(4):647–650. https://doi.org/10.1590/1678-457x.29516
- Koui EW, Soro D, Gnoumou JIK, Assidjo NE, Yao KB. Production of cashew apple wine enriched with Hibiscus sabdariffa extracts. Food and Nutrition Sciences. 2023;14(8):720–729. https://doi.org/10.4236/fns.2023.148047
- Ndong M, Faye SN, Bassama J, Cissã M. Stability of concentrated extracts of Hibiscus sabdariffa L. calyx during storage at different temperatures. African Journal of Food Science. 2018;12(12):347–352. https://doi.org/10.5897/AJFS2018.1694
- Abdel-Shafi S, Al-Mohammadi AR, Sitohy M, Mosa B, Ismaiel A, et al. Antimicrobial activity and chemical constitution of the crude, phenolic-rich extracts of Hibiscus sabdariffa, Brassica oleracea and Beta vulgaris. Molecules. 2019;24(23):4280. https://doi.org/10.3390/molecules24234280
- Karmana IW. Artikel Review: Bioaktivitas bunga rosella (Hibiscus sabdariffa L.) beserta pemanfaatannya. Educatoria: Jurnal Ilmiah Ilmu Pendidikan. 2023;3(3):208–216. https://doi.org/10.36312/educatoria.v3i3.200
- Hamwenye K, Shindaadhi H, Sivhute E, van Hal PH, Samundengu C. Phytochemical evaluation of Hibiscus sabdariffa powder, jam and yoghurt. Research Square. 2020. https://doi.org/10.21203/rs.3.rs-86484/v1
- Jiménez-Ferrer E, Alarcón-Alonso J, Aguilar-Rojas A, Zamilpa A, Jiménez-Ferrer CI, et al. Diuretic effect of compounds from Hibiscus sabdariffa by modulation of the aldosterone activity. Planta Medica. 2012;78(18):1893–1898. https://doi.org/10.1055/s-0032-1327864
- Arshad MS, Batool SA. Natural antimicrobials, their sources and food safety. In: Karunaratne DN, Pamunuwa G, editors. Food Additives. 2017. https://doi.org/10.5772/intechopen.70197
- Ravishankar S, Zhu L, Reyna-Granados J, Law B, Joens L, et al. Carvacrol and cinnamaldehyde inactivate antibiotic-resistant Salmonella enterica in buffer and on celery and oysters. Journal of Food Protection. 2010;73(2):234–240. https://doi.org/10.4315/0362-028X-73.2.234
- Friedman M. Antibiotic-resistant bacteria: Prevalence in food and inactivation by food-compatible compounds and plant extracts. Journal of Agricultural and Food Chemistry. 2015;63(15):3805–3822. https://doi.org/10.1021/acs.jafc.5b00778
- Han C, Wang J, Li Y, Cui Y. In vitro antimicrobial activity and effect on E. Coli integrity of cinnamon essential oil and rhubarb ethanol extract. Food Science and Technology Research. 2013;19(6):1155–1163. https://doi.org/10.3136/fstr.19.1155
- Basavegowda N, Baek KH. Synergistic antioxidant and antibacterial advantages of essential oils for food packaging applications. Biomolecules. 2021;11(9):1267. https://doi.org/10.3390/biom11091267
- Gomes J, Barbosa J, Teixeira P. The inhibitory concentration of natural food preservatives may be biased by the determination methods. Foods. 2021;10(5):1009. https://doi.org/10.3390/foods10051009
- Lee NK, Paik HD. Status, antimicrobial mechanism, and regulation of natural preservatives in livestock food systems. Food Science of Animal Resources. 2016;36(4):547–557. https://doi.org/10.5851/kosfa.2016.36.4.547
- Mirzaee H, Ariens E, Blaskovich MAT, Clark RJ, Schenk PM. Biostimulation of bacteria in liquid culture for identification of new antimicrobial compounds. Pharmaceuticals. 2021;14(12):1232. https://doi.org/10.3390/ph14121232
- Campos CA, Gerschenson LN, Flores SK. Development of edible films and coatings with antimicrobial activity. Food and Bioprocess Technology. 2011;4(6):849–875. https://doi.org/10.1007/s11947-010-0434-1
- Rawdkuen S, Suthiluk P, Kamhangwong D, Benjakul S. Mechanical, physico-chemical, and antimicrobial properties of gelatin-based film incorporated with catechin-lysozyme. Chemistry Central Journal. 2012;6:131. https://doi.org/10.1186/1752-153X-6-131
- Gómez‐Aldapa CA, Díaz‐Cruz CA, Castro‐Rosas J, Jiménez‐Regalado EJ, Velazquez G, et al. Development of antimicrobial biodegradable films based on corn starch with aqueous extract of Hibiscus sabdariffa L. starch – Stärke. 2021;73(1–2):2000096. https://doi.org/10.1002/star.202000096
- Sedillo-Torres IY, Hernández-Rangel ÁO, Gómez-y-Gómez Y, Cortés-Avalos D, García-Pérez BE, et al. Hibiscus acid from Hibiscus sabdariffa L. inhibits flagellar motility and cell invasion in Salmonella enterica. Molecules. 2022;27(3):655. https://doi.org/10.3390/molecules27030655
- Portillo-Torres LA, Bernardino-Nicanor A, Gómez-Aldapa CA, González-Montiel S, Rangel-Vargas E, et al. Hibiscus acid and chromatographic fractions from Hibiscus sabdariffa calyces: Antimicrobial activity against multidrug-resistant pathogenic bacteria. Antibiotics. 2019;8(4):218. https://doi.org/10.3390/antibiotics8040218
- Márquez-Rodríguez AS, Nevárez-Baca S, Lerma-Hernández JC, Hernández-Ochoa LR, Nevárez-Moorillon GV, et al. In vitro antibacterial activity of Hibiscus sabdariffa L. phenolic extract and its in situ application on shelf-life of beef meat. Foods. 2020;9(8):1080. https://doi.org/10.3390/foods9081080
- Hernández‐Carranza P, Heredia‐Soberanes K, Ruiz‐López II, Ochoa‐Velasco CE. Effect of impregnation‐osmodehydration with Hibiscus Sabdariffa extracts on the bioactive compounds and sensory acceptance of apple wedges: Fresh, convective dried, and stored. Journal of Food Processing and Preservation. 2022;46(11):1–13. https://doi.org/10.1111/jfpp.17110
- Herranz-López M, Olivares-Vicente M, Rodríguez Gallego E, Encinar JA, Pérez-Sánchez A, et al. Quercetin metabolites from Hibiscus Sabdariffa contribute to alleviate glucolipotoxicity-induced metabolic stress in vitro. Food and Chemical Toxicology. 2020;144:111606. https://doi.org/10.1016/j.fct.2020.111606
- Izquierdo-Vega J, Arteaga-Badillo D, Sánchez-Gutiérrez M, Morales-González J, Vargas-Mendoza N, et al. Organic acids from roselle (Hibiscus sabdariffa L.) – A brief review of its pharmacological effects. Biomedicines. 2020;8(5):100. https://doi.org/10.3390/biomedicines8050100
- Chongwilaikasem N, Sithisarn P, Rojsanga P, Sithisarn P. Green extraction and partial purification of roselle (Hibiscus sabdariffa L.) extracts with high amounts of phytochemicals and in vitro antioxidant and antibacterial effects. Journal of Food Science. 2024;89(12):8819–8835. https://doi.org/10.1111/1750-3841.17418
- Hernández-Hernández FA, Gómez-Aldapa CA, Castro-Rosas J, Vargas-León EA, Gutierrez MC, et al. Hibiscus sabdariffa L. extract as a natural additive in food packaging biodegradable films to improve antioxidant, antimicrobial, and physicochemical properties. Plant Foods for Human Nutrition. 2024;79:285–291. https://doi.org/10.1007/s11130-024-01189-4
- Higginbotham KL, Burris KP, Zivanovic S, Davidson PM, Stewart CN. Antimicrobial activity of Hibiscus sabdariffa aqueous extracts against Escherichia coli O157:H7 and Staphylococcus aureus in a microbiological medium and milk of various fat concentrations. Journal of Food Protection. 2014;77(2):262–268. https://doi.org/10.4315/0362-028X.JFP-13-313
- Tayel AA, Bahnasy AG, Mazrou KE, Alasmari A, El Rabey HA, et al. Biopreservation and quality enhancement of fish surimi using colorant plant extracts. Journal of Food Quality. 2021;2021:1–8. https://doi.org/10.1155/2021/6624565
- Gómez-Aldapa CA, Rangel-Vargas E, Torres-Vitela MR, Villarruel-López A, Acevedo-Sandoval OA, et al. Antibacterial activities of Hibiscus sabdariffa extracts and chemical sanitizers directly on green leaves contaminated with foodborne pathogens. Journal of Food Protection. 2018;81(2):209–217. https://doi.org/10.4315/0362-028X.JFP-17-053
- Cruz-Gálvez AM, Castro-Rosas J, Rodríguez-Marín ML, Cadena-Ramírez A, Tellez-Jurado A, et al. Antimicrobial activity and physicochemical characterization of a potato starch-based film containing acetonic and methanolic extracts of Hibiscus sabdariffa for use in sausage. LWT. 2018;93:300–305. https://doi.org/10.1016/j.lwt.2018.02.064
- Higginbotham KL, Burris KP, Zivanovic S, Davidson PM, Stewart CN. Aqueous extracts of Hibiscus sabdariffa calyces as an antimicrobial rinse on hot dogs against Listeria monocytogenes and methicillin-resistant Staphylococcus aureus. Food Control. 2014;40:274–277. https://doi.org/10.1016/j.foodcont.2013.12.011
- Liu K, Tsao S, Yin M. In vitro antibacterial activity of roselle calyx and protocatechuic acid. Phytotherapy Research. 2005;19(11):942–945. https://doi.org/10.1002/ptr.1760
- Borrás-Linares I, Fernández-Arroyo S, Arráez-Roman D, Palmeros-Suárez PA, Del Val-Díaz R, et al. Characterization of phenolic compounds, anthocyanidin, antioxidant and antimicrobial activity of 25 varieties of Mexican Roselle (Hibiscus sabdariffa). Industrial Crops and Products. 2015;69:385–394. https://doi.org/10.1016/j.indcrop.2015.02.053
- Cheok CY, Ragunathan A. Anthocyanin degradation kinetics and thermodynamic analysis of Hibiscus rosa-sinensis L. Clitoria ternatea L. and Hibiscus sabdariffa L. Progress in Energy and Environment. 2022;19:1–12. https://doi.org/10.37934/progee.19.1.112
- Ramirez‐Rodrigues MM, Plaza ML, Azeredo A, Balaban MO, Marshall MR. Physicochemical and phytochemical properties of cold and hot water extraction from Hibiscus sabdariffa. Journal of Food Science. 2011;76(3):428–435. https://doi.org/10.1111/j.1750-3841.2011.02091.x
- Morales-Cabrera M, Hernández-Morales J, Leyva-Rúelas G, Salinas-Moreno Y, Soto-Rojas L, et al. Influence of variety and extraction solvent on antibacterial activity of roselle (Hibiscus sabdariffa L.) calyxes. Journal of Medicinal Plants Research. 2013;7(31):2319–2322. https://doi.org/10.5897/JMPR12.1242
- Da-Costa-Rocha I, Bonnlaender B, Sievers H, Pischel I, Heinrich M. Hibiscus sabdariffa L. – A phytochemical and pharmacological review. Food Chemistry. 2014;165:424–443. https://doi.org/10.1016/j.foodchem.2014.05.002
- Ali BH, Wabel NA, Blunden G. Phytochemical, pharmacological and toxicological aspects of Hibiscus sabdariffa L.: A review. Phytotherapy Research. 2005;19(5):369–375. https://doi.org/10.1002/ptr.1628
- Lin HH, Chen JH, Wang CJ. Chemopreventive properties and molecular mechanisms of the bioactive compounds in Hibiscus sabdariffa Linne. Current Medicinal Chemistry. 2011;18(8):1245–1254. https://doi.org/10.2174/092986711795029663
- Gonelimali FD, Lin J, Miao W, Xuan J, Charles F, et al. Antimicrobial properties and mechanism of action of some plant extracts against food pathogens and spoilage microorganisms. Frontiers in Microbiology. 2018;9:1639. https://doi.org/10.3389/fmicb.2018.01639
- Soto-Robles CA, Luque PA, Gómez-Gutiérrez CM, Nava O, Vilchis-Nestor AR, et al. Study on the effect of the concentration of Hibiscus sabdariffa extract on the green synthesis of ZnO nanoparticles. Results in Physics. 2019;15:102807. https://doi.org/10.1016/j.rinp.2019.102807
- El-Sayed SM, El-Sayed HS, Ibrahim OA, Youssef AM. Rational design of chitosan/guar gum/zinc oxide bionanocomposites based on Roselle calyx extract for Ras cheese coating. Carbohydrate Polymers. 2020;239:116234. https://doi.org/10.1016/j.carbpol.2020.116234
- Chao CY, Yin MC. Antibacterial effects of roselle calyx extracts and protocatechuic acid in ground beef and apple juice. Foodborne Pathogens and Disease. 2009;6(2):201–206. https://doi.org/10.1089/fpd.2008.0187
- Jabeur I, Pereira E, Barros L, Calhelha RC, Soković M, et al. Hibiscus sabdariffa L. as a source of nutrients, bioactive compounds and colouring agents. Food Research International. 2017;100(Part 1):717–723. https://doi.org/10.1016/j.foodres.2017.07.073
- Olaleye MT. Cytotoxicity and antibacterial activity of Methanolic extract of Hibiscus sabdariffa. Journal of Medicinal Plants Research. 2007;1(1):9–13.
- Barrajón-Catalán E, Herranz-López M, Joven J, Segura-Carretero A, Alonso-Villaverde C, et al. Molecular promiscuity of plant polyphenols in the management of age-related diseases: Far beyond their antioxidant properties. In: Camps J, editor. Oxidative stress and inflammation in non-communicable diseases – molecular mechanisms and perspectives in therapeutics. Cham: Springer International Publishing; 2014, pp. 141–159. https://doi.org/10.1007/978-3-319-07320-0_11
- Darwish RM, Aburjai TA. Effect of ethnomedicinal plants used in folklore medicine in Jordan as antibiotic resistant inhibitors on Escherichia coli. BMC Complementary and Alternative Medicine. 2010;10(1):9. https://doi.org/10.1186/1472-6882-10-9
- Abdelghany AM, Menazea AA, Ismail AM. Synthesis, characterization and antimicrobial activity of Chitosan/Polyvinyl Alcohol blend doped with Hibiscus sabdariffa L. extract. Journal of Molecular Structure. 2019;1197:603–609. https://doi.org/10.1016/j.molstruc.2019.07.089
- Ochoa-Velasco CE, Ruiz-López II. Mass transfer modeling of the antioxidant extraction of roselle flower (Hibiscus sabdariffa). Journal of Food Science and Technology. 2019;56:1008–1015. https://doi.org/10.1007/s13197-018-03567-8
- Hassan STS, Berchová K, Majerová M, Pokorná M, Švajdlenka E. In vitro synergistic effect of Hibiscus Sabdariffa aqueous extract in combination with standard antibiotics against Helicobacter pylori clinical isolates. Pharmaceutical Biology. 2016;54(9):1736–1740. https://doi.org/10.3109/13880209.2015.1126618
- Purba H, Simanjuntak HA, Situmorang R. Phytochemical screening of bunga rosella (Hibiscus sabdariffa L.) and antimicrobial activity test. Jurnal Pendidikan Kimia. 2020;12(2):70–78. https://doi.org/10.24114/jpkim.v12i2.19398
- Venkatesan K, Venkatesan S, Manivannan N. Antibacterial activity of Hibiscus sabdariffa (rosella) using methanolic extract. Journal of Pharmacy and Bioallied Sciences. 2024;16(Suppl 2):S1191–S1194. https://doi.org/10.4103/jpbs.jpbs_527_23
- Lusida TTE, Hermanto B, Sudarno S. The antibacterial effect of roselle (Hibiscus sabdariffa) extract against Staphylococcus epidermidis in vitro. Indonesian Journal of Tropical and Infectious Disease. 2017;6(4):88. https://doi.org/10.20473/ijtid.v6i4.3757
- Mohamed-Salem R, Rodríguez Fernández C, Nieto-Pelegrín E, Conde-Valentín B, Rumbero A, et al. Aqueous extract of Hibiscus sabdariffa inhibits pedestal induction by enteropathogenic E. coli and promotes bacterial filamentation in vitro. Plos One. 2019;14(3):e0213580. https://doi.org/10.1371/journal.pone.0213580
- Fu Y, Sarkar P, Bhunia AK, Yao Y. Delivery systems of antimicrobial compounds to food. Trends in Food Science & Technology. 2016;57(Part A):165–177. https://doi.org/10.1016/j.tifs.2016.09.013
- Maurya A, Singh VK, Das S, Prasad J, Kedia A, et al. Essential oil nanoemulsion as eco-friendly and safe preservative: Bioefficacy against microbial food deterioration and toxin secretion, mode of action, and future opportunities. Frontiers in Microbiology. 2021;12:751062. https://doi.org/10.3389/fmicb.2021.751062
- Perricone M, Arace E, Corbo MR, Sinigaglia M, Bevilacqua A. Bioactivity of essential oils: A review on their interaction with food components. Frontiers in Microbiology. 2015;6:76. https://doi.org/10.3389/fmicb.2015.00076
- Basak S, Guha P. A review on antifungal activity and mode of action of essential oils and their delivery as nano-sized oil droplets in food system. Journal of Food Science and Technology. 2018;55(12):4701–4710. https://doi.org/10.1007/s13197-018-3394-5
- Rao J, Chen B, McClements DJ. Improving the efficacy of essential oils as antimicrobials in foods: Mechanisms of action. Annual Review of Food Science and Technology. 2019;10(1):365–387. https://doi.org/10.1146/annurev-food-032818-121727
- Rawdkuen S. Edible films incorporated with active compounds: Their properties and application. In: Var I, Uzunlu S, editors. Active Antimicrobial Food Packaging. UK: IntechOpen; 2019. https://doi.org/10.5772/intechopen.80707
- Liao W, Badri W, Dumas E, Ghnimi S, Elaissari A, et al. Nanoencapsulation of essential oils as natural food antimicrobial agents: An overview. Applied Sciences. 2021;11(13):5778. https://doi.org/10.3390/app11135778
- Irkin R, Esmer OK. Novel food packaging systems with natural antimicrobial agents. Journal of Food Science and Technology. 2015;52(10):6095–6111. https://doi.org/10.1007/s13197-015-1780-9
- Vodnar DC, Pop OL, Dulf FV, Socaciu C. Antimicrobial efficiency of edible films in food industry. Notulae Botanicae Horti Agrobotanici Cluj-Napoca. 2015;43(2):302–312. https://doi.org/10.15835/nbha.43.2.10048
- Suzuki R, Ohno H, Murakami T, Shirataki Y. Improving quality control of yucca extracts used as food additives by screening antimicrobial activity using NMR metabolomics. Journal of Natural Medicines. 2020;74:306–310. https://doi.org/10.1007/s11418-019-01370-z
- Gonçalves LA, Lorenzo JM, Trindade MA. Fruit and agro-industrial waste extracts as potential antimicrobials in meat products: A brief review. Foods. 2021;10(7):1469. https://doi.org/10.3390/foods10071469
- Teshome E, Forsido SF, Rupasinghe HPV, Olika Keyata E. Potentials of natural preservatives to enhance food safety and shelf life: A review. The Scientific World Journal. 2022;2022:1–11. https://doi.org/10.1155/2022/9901018
- Kashiri M, Cerisuelo JP, Domínguez I, López-Carballo G, Hernández-Muñoz P, et al. Novel antimicrobial zein film for controlled release of lauroyl arginate (LAE). Food Hydrocolloids. 2016;61:547–554. https://doi.org/10.1016/j.foodhyd.2016.06.012
- Racowski I, Almeida CPM, Silva CMA, De Carvalho GT. Elaboration of an antimicrobial, biodegradable and aromatic film against the natural contamination of sliced mozzarella cheese. European Journal of Engineering Research and Science. 2019;4(6):1–5. https://doi.org/10.24018/ejeng.2019.4.6.1356
- Martínez Viedma P, Grande Burgos MJ, Pérez Pulido R, Soriano B, Gálvez A, et al. Inhibition of Salmonella Enterica and Listeria monocytogenes in tofu by activated plastic films. International Journal of Research Studies in Microbiology and Biotechnology. 2016;2(2):25–29. https://doi.org/10.20431/2454-9428.0202005
- Efrati R, Natan M, Pelah A, Haberer A, Banin E, et al. The effect of polyethylene crystallinity and polarity on thermal stability and controlled release of essential oils in antimicrobial films. Journal of Applied Polymer Science. 2014;131(11):1–11. https://doi.org/10.1002/app.40309
- Mei L, Wang Q. Advances in using nanotechnology structuring approaches for improving food packaging. Annual Review of Food Science and Technology. 2020;11: 339–364. https://doi.org/10.1146/annurev-food-032519-051804
- Bumbudsanpharoke N, Lee W, Ko S. A comprehensive feasibility study on the properties of LDPE‐Ag nanocomposites for food packaging applications. Polymer Composites. 2018;39(9):3178–3186. https://doi.org/10.1002/pc.24325
- Fitrotunnisa Q, Arsianti A, Tejaputri NA, Qorina F. Antioxidative activity and phytochemistry profile of Hibiscus sabdariffa herb extracts. International Journal of Applied Pharmaceutics. 2019;11(6)29–32. https://doi.org/10.22159/ijap.2019.v11s6.33532
- Yeasmin T, Ali H, Yesmin R, Islam M, Hoshen A, et al. Growth inhibition and apoptosis of ehrlich ascites carcinoma cells by methanol extract from the calyx of Hibiscus sabdariffa Linn. Central Asian Journal of Medical Sciences. 2018;4(2):155–165. https://doi.org/10.24079/cajms.2018.06.007
- Inthima P, Supaibulwatana K. Comparative growth and bacoside production in diploid and tetraploid Bacopa monnieri (L.) Wettst. cultivated indoors via hydroponic and soil culture systems. Horticulturae. 2024;10(6):574. https://doi.org/10.3390/horticulturae10060574
- Wawrosch C, Zotchev SB. Production of bioactive plant secondary metabolites through in vitro technologies – status and outlook. Applied Microbiology and Biotechnology. 2021;105:6649–6668. https://doi.org/10.1007/s00253-021-11539-w
- Sánchez-Suárez J, Garnica-Agudelo M, Villamil L, Díaz L, Coy-Barrera E. Bioactivity and biotechnological overview of naturally occurring compounds from the dinoflagellate family Symbiodiniaceae: A systematic review. The Scientific World Journal. 2021;2021:1–10. https://doi.org/10.1155/2021/1983589
- Bermejo E, Rayen F, Behnam T. Microalgae culture quality indicators: A review. Critical Reviews in Biotechnology. 2021;41(4):457–473. https://doi.org/10.1080/07388551.2020.1854672
- Agarwal A, Jeevanandham S, Sangam S, Chakraborty A, Mukherjee M. Exploring the role of carbon-based nanomaterials in microalgae for the sustainable production of bioactive compounds and beyond. ACS Omega. 2022;7(26):22061–22072. https://doi.org/10.1021/acsomega.2c01009
- Yembaturova EYu, Cheryatova YS. Transgenic medicinal plants as producers of bioactive substances. Ecological genetics. 2023;21(3S):41–42. https://doi.org/10.17816/ecogen567947
- Gilbert-López B, Barranco A, Herrero M, Cifuentes A, Ibáñez E. Development of new green processes for the recovery of bioactives from Phaeodactylum tricornutum. Food Research International. 2017;99(Part 3):1056–1065. https://doi.org/10.1016/j.foodres.2016.04.022
- Muñóz-Almagro N, Gilbert-López B, Carmen PRM, García-Fernandez Y, Almeida C, et al. Exploring the microalga Euglena cantabrica by pressurized liquid extraction to obtain bioactive compounds. Marine Drugs. 2020;18(6):308. https://doi.org/10.3390/md18060308
- Heemann ACW, Heemann R, Kalegari P, Spier MR, Santin E. Enzyme-assisted extraction of polyphenols from green yerba mate. Brazilian Journal of Food Technology. 2019;22:e2017222. https://doi.org/10.1590/1981-6723.22217
- Santos SSD, Paraíso CM, Rodrigues LM, Madrona GS. Agro-industrial waste as a source of bioactive compounds: Ultrasound-assisted extraction from blueberry (Vaccinium myrtillus) and raspberry (Rubus idaeus) pomace. Acta Scientiarum. Technology. 2021;43(1):e55564. https://doi.org/10.4025/actascitechnol.v43i1.55567
- Thomas AA, Varghese RM, Rajeshkumar S. Antimicrobial effects of copper nanoparticles with green tea and neem formulation. Bioinformation. 2022;18(3):284–288. https://doi.org/10.6026/97320630018284
- Thomas AA, Varghese RM, Rajeshkumar S. Green synthesis of copper nanoparticles using green tea and neem formulation and assessment if its antimicrobial effects. Indian Journal of Forensic Medicine & Toxicology. 2022;16(4):119–124. https://doi.org/10.37506/ijfmt.v16i4.18550
- Mahanty A, Mishra S, Bosu R, Maurya U, Netam SP, et al. Phytoextracts-synthesized silver nanoparticles inhibit bacterial fish pathogen Aeromonas hydrophila. Indian Journal of Microbiology. 2013;53(4):438–446. https://doi.org/10.1007/s12088-013-0409-9
- Salayová A, Bedlovičová Z, Daneu N, Baláž M, Lukáčová Bujňáková Z, et al. Green synthesis of silver nanoparticles with antibacterial activity using various medicinal plant extracts: Morphology and antibacterial efficacy. Nanomaterials. 2021;11(4):1005. https://doi.org/10.3390/nano11041005
- Hassabo A, Kamel M. Anti-microbial finishing for natural textile fabrics. Journal of Textiles, Coloration and Polymer Science. 2021. https://doi.org/10.21608/jtcps.2021.72333.1054
- Peng CH, Chyau CC, Chan KC, Chan TH, Wang CJ, et al. Hibiscus sabdariffa polyphenolic extract inhibits hyperglycemia, hyperlipidemia, and glycation-oxidative stress while improving insulin resistance. Journal of Agricultural and Food Chemistry. 2011;59(18):9901–9909. https://doi.org/10.1021/jf2022379
- Joshi SS, Dice L, D’Souza DH. Aqueous extracts of Hibiscus sabdariffa calyces decrease hepatitis a virus and human norovirus surrogate titers. Food and Environmental Virology. 2015;7:366–373. https://doi.org/10.1007/s12560-015-9209-1
- Ifie I, Marshall LJ, Ho P, Williamson G. Hibiscus sabdariffa (Roselle) extracts and wine: Phytochemical profile, physicochemical properties, and carbohydrase inhibition. Journal of Agricultural and Food Chemistry. 2016;64(24):4921–4931. https://doi.org/10.1021/acs.jafc.6b01246
- Iloghalu U, Holmes B, Khatiwada J, Williams LL. Selected plant extracts show antiviral effects against murine norovirus surrogate. Advances in Microbiology. 2019;9(4):372–384. https://doi.org/10.4236/aim.2019.94022
- Abid MT, Banna MHA, Hamiduzzaman M, Seidu A, Kundu S, et al. Assessment of food safety knowledge, attitudes and practices of street food vendors in Chattogram city, Bangladesh: A cross‐sectional study. Public Health Challenges. 2022;1(3):e16. https://doi.org/10.1002/puh2.16
- Abrahale K, Sousa S, Albuquerque G, Padrão P, Lunet N. Street food research worldwide: A scoping review. Journal of Human Nutrition and Dietetics. 2019;32(2):152–174. https://doi.org/10.1111/jhn.12604
- Ahmed MJ, Ali M, Alam KE, Mamun M, Bhuiyan MIH, et al. Assessing knowledge, attitude, and practices (KAP) of food safety among dhaka city’s street food vendors: A public health issue. Research Square. 2024. https://doi.org/10.21203/rs.3.rs-4737912/v1
- Bekele TH, de Vries JJ, Trijsburg L, Feskens E, Covic N, et al. Methodology for developing and evaluating food-based dietary guidelines and a healthy eating index for Ethiopia: A study protocol. BMJ Open. 2019;9(7):e027846. https://doi.org/10.1136/bmjopen-2018-027846
- Putri M, Ali Z, Jannah RB, Rahayu S, Mulyati T, et al. Humberger cassava: The solution of today’s food choices in the global era, utilizing Indonesia’s natural resources. Probilitas. 2022;1(1):8–13. https://doi.org/10.54482/probilitas.v1i01.81
- Joshi P, Karn SK, Koirala P. Strengthening food safety governance in Nepal through collaborative capacity development and private sector engagement. Journal of Agriculture and Environment. 2023;24:235–242. https://doi.org/10.3126/aej.v24i01.58197
- Gondal MUA, Khan MA, Haseeb A, Albarakati HM, Shabaz M. A secure food supply chain solution: Blockchain and IoT-enabled container to enhance the efficiency of shipment for strawberry supply chain. Frontiers in Sustainable Food Systems. 2023;7:1294829. https://doi.org/10.3389/fsufs.2023.1294829
- Jabbar S, Choudhary R, Zanib A, Shiekh S, Abbas G, et al. Securing public health: IoT and big data in food safety traceability. Pakistan Journal of Science. 2024;76(01):141–153. https://doi.org/10.57041/pjs.v76i01.1109
- Nordhagen S, Lee J, Onuigbo-Chatta N, Okoruwa A, Monterrosa E, et al. What is safe and how much does it matter? Food vendors’ and consumers’ views on food safety in urban Nigeria. Foods. 2022;11(2):225. https://doi.org/10.3390/foods11020225
- Liverpool-Tasie LSO, Wineman A, Resnick D. Divergent beliefs about food safety and affordability in Nigeria. Global Food Security. 2024;41:100753. https://doi.org/10.1016/j.gfs.2024.100753