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Home >Foods and Raw Materials > Archive > Volume 8, Issue 2, 2020 > Antimicrobial activity of mono- and polynuclear platinum and palladium complexes
ISSN 2308-4057 (Print),
ISSN 2310-9599 (Online)

Antimicrobial activity of mono- and polynuclear platinum and palladium complexes

Olesya V. Salishcheva a
,
Alexander Yu. Prosekov a
Affiliation
a Kemerovo State University, Kemerovo, Russia
Copyright ©Salishcheva et al. This is an open access article distributed under the terms of the Creative Commons Attribution 4.0. (http://creativecommons.org/licenses/by/4.0/), allowing third parties to copy and redistribute the material in any medium or format and to remix, transform, and build upon the material for any purpose, even commercially, provided the original work is properly cited and states its license.
Received 16 March, 2020 | Accepted in revised form 23 April, 2020 | Published 25 August, 2020
DOI: http://doi.org/10.21603/2308-4057-2020-2-298-311
Abstract
Introduction. Infectious diseases remain a serious threat to humanity worldwide as bacterial pathogens grow more diverse. Bacteria, fungi, and parasites develop resistance to clinically approved antimicrobials, which reduces the efficacy of available drugs and treatment measures. As a result, there is an ever growing demand for new highly effective pharmaceuticals. This review describes mono- and polynuclear platinum and palladium complexes with antimicrobial properties. We compared several groups of antibacterial agents: antibiotics, antioxidant biologically active substances, antimicrobial nanoparticles, nanocomposite materials, biopolymers, micellar systems, and plant extracts.
Study objects and methods. The review covered relevant articles published in Web of Science, Scopus, and Russian Science Citation Index for the last decade. The list of descriptors included such terms as mononuclear and binuclear complexes of platinum, palladium, and antimicrobial activity.
Results and discussion. Chelates of platinum, palladium, silver, iridium, rhodium, ruthenium, cobalt, and nickel are popular therapeutic agents. Their antimicrobial activity against pathogenic microorganisms can be enhanced by increasing their bioavailability. Metalbased drugs facilitate the transport of organic ligands towards the bacterial cell. The nature of the ligand and its coordination change the thermodynamic stability, kinetic lability, and lipophilic properties of the complex, as well as the reactivity of the central atom. Polynuclear platinum and palladium complexes contain two or more bound metal (coordinate) centers. Covalent bonding with bacterial DNA enables them to form a type of DNA adducts, which is completely different from that of mononuclear complexes.
Conclusion. Metal-based drugs with functional monodentate ligands exhibit a greater antimicrobial effect compared to free ligands. Poly- and heteronuclear complexes can increase the number of active centers that block the action of bacterial cells. When combined with other antibacterial agents, they provide a synergistic effect, which makes them a promising subject of further research.
Keywords
Antimicrobial activity, antibacterial activity, antitumor activity, mononuclear complexes, polynuclear complexes, platinum (II), palladium (II), platinum (IV)
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How to quote?
Salishcheva OV, Prosekov AYu. Antimicrobial activity of mono- and polynuclear platinum and palladium complexes. Foods and Raw Materials. 2020;8(2):298–311. DOI: http://doi.org/10.21603/2308-4057-2020-2-298-311
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